ID  Q9NUQ2;
PN  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon;
GN  AGPAT5;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21173190}; Multi-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:21173190}. Mitochondrion {ECO:0000269|PubMed:21173190}.
DR  UNIPROT: Q9NUQ2;
DR  UNIPROT: Q8IZ47;
DR  UNIPROT: Q9BQG4;
DR  Pfam: PF16076;
DR  Pfam: PF01553;
DR  OMIM: 614796;
DR  DisGeNET: 55326;
DE  Function: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl- CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190). {ECO:0000269|PubMed:21173190}.
DE  Reference Proteome: Yes;
DE  Interaction: O00716; IntAct: EBI-7600105; Score: 0.35
DE  Interaction: Q9UMX0; IntAct: EBI-10314214; Score: 0.72
DE  Interaction: Q96BA8; IntAct: EBI-24523147; Score: 0.56
DE  Interaction: Q8NBI2; IntAct: EBI-24754929; Score: 0.56
DE  Interaction: Q9NY72; IntAct: EBI-23905509; Score: 0.56
DE  Interaction: Q9Y320; IntAct: EBI-25241264; Score: 0.56
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: P32970; IntAct: EBI-21512742; Score: 0.35
DE  Interaction: Q6UWJ1; IntAct: EBI-21540820; Score: 0.35
DE  Interaction: P35414; IntAct: EBI-21559824; Score: 0.35
DE  Interaction: P13473; IntAct: EBI-21591420; Score: 0.35
DE  Interaction: P55290; IntAct: EBI-21736384; Score: 0.35
DE  Interaction: P61586; IntAct: EBI-25394264; Score: 0.35
GO  GO:0012505;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005741;
GO  GO:0005739;
GO  GO:0005635;
GO  GO:0005730;
GO  GO:0003841;
GO  GO:0016746;
GO  GO:0006639;
GO  GO:0016024;
GO  GO:0002244;
GO  GO:0006654;
GO  GO:0008654;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MLLSLVLHTYSMRYLLPSVVLLGTAPTYVLAWGVWRLLSAFLPARFYQALDDRLYCVYQSMVLFFFENYTGVQILLYGDL
SQ  PKNKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYV
SQ  DAGTPMYLVIFPEGTRYNPEQTKVLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVVYEGKDDGGQ
SQ  RRESPTMTEFLCKECPKIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYESPDPERRKRFPGKSVNSKLSIKK
SQ  TLPSMLILSGLTAGMLMTDAGRKLYVNTWIYGTLLGCLWVTIKA
//