ID  Q9NWT6;
PN  Hypoxia-inducible factor 1-alpha inhibitor;
GN  HIF1AN;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.
DR  UNIPROT: Q9NWT6;
DR  UNIPROT: D3DR69;
DR  UNIPROT: Q5W147;
DR  UNIPROT: Q969Q7;
DR  UNIPROT: Q9NPV5;
DR  PDB: 1H2K;
DR  PDB: 1H2L;
DR  PDB: 1H2M;
DR  PDB: 1H2N;
DR  PDB: 1IZ3;
DR  PDB: 1MZE;
DR  PDB: 1MZF;
DR  PDB: 1YCI;
DR  PDB: 2CGN;
DR  PDB: 2CGO;
DR  PDB: 2ILM;
DR  PDB: 2W0X;
DR  PDB: 2WA3;
DR  PDB: 2WA4;
DR  PDB: 2XUM;
DR  PDB: 2Y0I;
DR  PDB: 2YC0;
DR  PDB: 2YDE;
DR  PDB: 3D8C;
DR  PDB: 3KCX;
DR  PDB: 3KCY;
DR  PDB: 3OD4;
DR  PDB: 3P3N;
DR  PDB: 3P3P;
DR  PDB: 4AI8;
DR  PDB: 4B7E;
DR  PDB: 4B7K;
DR  PDB: 4BIO;
DR  PDB: 4JAA;
DR  PDB: 4NR1;
DR  PDB: 4Z1V;
DR  PDB: 4Z2W;
DR  PDB: 5JWK;
DR  PDB: 5JWL;
DR  PDB: 5JWP;
DR  PDB: 5OP6;
DR  PDB: 5OP8;
DR  PDB: 5OPC;
DR  PDB: 6H9J;
DR  PDB: 6HA6;
DR  PDB: 6HC8;
DR  PDB: 6HKP;
DR  PDB: 6HL5;
DR  PDB: 6HL6;
DR  PDB: 6RUJ;
DR  PDB: 7A1J;
DR  PDB: 7A1K;
DR  PDB: 7A1L;
DR  PDB: 7A1M;
DR  PDB: 7A1N;
DR  PDB: 7A1O;
DR  PDB: 7A1P;
DR  PDB: 7A1Q;
DR  PDB: 7A1S;
DR  Pfam: PF13621;
DR  PROSITE: PS51184;
DR  OMIM: 606615;
DR  DisGeNET: 55662;
DE  Function: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.
DE  Reference Proteome: Yes;
DE  Interaction: O75190; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O95271; IntAct: EBI-8565753; Score: 0.78
DE  Interaction: O96018; IntAct: EBI-15099018; Score: 0.75
DE  Interaction: P58546; IntAct: EBI-15602804; Score: 0.44
DE  Interaction: Q06787; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q86UE4; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q8WXH0; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9H4L5; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q9NUQ3; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q96DX5; IntAct: EBI-754615; Score: 0.78
DE  Interaction: Q8WXK3; IntAct: EBI-755812; Score: 0.55
DE  Interaction: Q9Y283; IntAct: EBI-759370; Score: 0.64
DE  Interaction: Q16665; IntAct: EBI-1035055; Score: 0.92
DE  Interaction: Q6GQQ9; IntAct: EBI-2510717; Score: 0.56
DE  Interaction: Q9H2K2; IntAct: EBI-8565642; Score: 0.74
DE  Interaction: Q8TAK5; IntAct: EBI-8565789; Score: 0.44
DE  Interaction: Q9HBA0; IntAct: EBI-8565771; Score: 0.44
DE  Interaction: Q8IY67; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P54132; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8NB46; IntAct: EBI-12502476; Score: 0.64
DE  Interaction: Q05823; IntAct: EBI-12502476; Score: 0.79
DE  Interaction: Q9NVH0; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9NWX5; IntAct: EBI-12502476; Score: 0.53
DE  Interaction: Q68DC2; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9NU02; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O95218; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q969S3; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8N5A5; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9NUD5; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8WYQ9; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q86T24; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9BQA1; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q96MT7; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9P0L0; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q14157; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9UPQ9; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9UM00; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9Y4G6; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q99081; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q15370; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q15369; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q92844; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9UNL2; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9Y2K2; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P60468; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O43159; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P62847; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P62841; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q5VT52; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P61927; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P61353; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P57078; IntAct: EBI-12502476; Score: 0.50
DE  Interaction: Q7L0Y3; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q04206; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9HCJ3; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q2TAL8; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O00487; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9UNM6; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O75832; IntAct: EBI-12502476; Score: 0.59
DE  Interaction: P62195; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P35998; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q5H9R7; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9UPN7; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O15355; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P62875; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P30876; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q4KWH8; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O60733; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8IZ21; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P08237; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8N3A8; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9BXW6; IntAct: EBI-12502476; Score: 0.53
DE  Interaction: Q9H857; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9UM47; IntAct: EBI-12502476; Score: 0.53
DE  Interaction: Q04721; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9Y3T9; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O00221; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P25963; IntAct: EBI-12502476; Score: 0.73
DE  Interaction: Q00653; IntAct: EBI-12502476; Score: 0.53
DE  Interaction: Q9P032; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9Y6Q9; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9HCH0; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P41227; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9NZJ7; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8TE76; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q5TCX8; IntAct: EBI-12502476; Score: 0.64
DE  Interaction: Q15773; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q96AX9; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O43318; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q7L5Y9; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9BRK4; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P83369; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9ULH0; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8N163; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q7LBC6; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q96SI1; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q13418; IntAct: EBI-12502476; Score: 0.59
DE  Interaction: Q12894; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9ULT8; IntAct: EBI-12502476; Score: 0.64
DE  Interaction: Q00341; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O15379; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9Y450; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9H6D7; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8IYU2; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9UKJ3; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O60547; IntAct: EBI-12502476; Score: 0.53
DE  Interaction: Q9NRA8; IntAct: EBI-12502476; Score: 0.53
DE  Interaction: P06730; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9H9B1; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q96F86; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9Y678; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: A5YKK6; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q99439; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q96ST8; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q5VT06; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q12834; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8WXE0; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9UKZ1; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9BY42; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q6ZUT1; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: P20290; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9NVI7; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8NBU5; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9H765; IntAct: EBI-12502476; Score: 0.64
DE  Interaction: P27540; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q92625; IntAct: EBI-12502476; Score: 0.64
DE  Interaction: Q9ULJ7; IntAct: EBI-24286767; Score: 0.56
DE  Interaction: Q8N8A2; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: O15084; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q96NW4; IntAct: EBI-12502476; Score: 0.53
DE  Interaction: O75179; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q8IWZ3; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q9P2R3; IntAct: EBI-12502476; Score: 0.35
DE  Interaction: Q96FW1; IntAct: EBI-10770028; Score: 0.70
DE  Interaction: P46531; IntAct: EBI-11473706; Score: 0.44
DE  Interaction: P19838; IntAct: EBI-11322417; Score: 0.74
DE  Interaction: P47086; IntAct: EBI-11532399; Score: 0.56
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: Q6PG48; IntAct: EBI-24615512; Score: 0.56
DE  Interaction: Q7Z713; IntAct: EBI-24425210; Score: 0.56
DE  Interaction: Q9H672; IntAct: EBI-24534882; Score: 0.56
DE  Interaction: Q8NFD2; IntAct: EBI-25272595; Score: 0.67
DE  Interaction: Q96P71; IntAct: EBI-15098946; Score: 0.40
DE  Interaction: Q9Y575; IntAct: EBI-21571836; Score: 0.35
DE  Interaction: Q9UPU5; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q9UHD2; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q9H6R7; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q9BQS8; IntAct: EBI-21638930; Score: 0.53
DE  Interaction: Q8WXD9; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q8TES7; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q8TBX8; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q15653; IntAct: EBI-21638930; Score: 0.53
DE  Interaction: Q05086; IntAct: EBI-21638930; Score: 0.53
DE  Interaction: Q04864; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q01484; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: P78356; IntAct: EBI-21638930; Score: 0.53
DE  Interaction: P55196; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: P47974; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: P40222; IntAct: EBI-21638930; Score: 0.53
DE  Interaction: Q12955; IntAct: EBI-21638930; Score: 0.35
DE  Interaction: Q8WXI3; IntAct: EBI-21754620; Score: 0.35
DE  Interaction: Q9BW85; IntAct: EBI-21758292; Score: 0.35
DE  Interaction: Q9Y574; IntAct: EBI-21801297; Score: 0.35
DE  Interaction: Q8WVL7; IntAct: EBI-21811862; Score: 0.69
DE  Interaction: Q3KP44; IntAct: EBI-21876401; Score: 0.35
DE  Interaction: Q96NS5; IntAct: EBI-21897846; Score: 0.35
DE  Interaction: Q495B1; IntAct: EBI-21900536; Score: 0.40
DE  Interaction: Q9UK73; IntAct: EBI-15602843; Score: 0.59
DE  Interaction: Q9BZF9; IntAct: EBI-15602883; Score: 0.51
DE  Interaction: Q06547; IntAct: EBI-15603005; Score: 0.44
DE  Interaction: P55273; IntAct: EBI-15603110; Score: 0.44
DE  Interaction: O14974; IntAct: EBI-15603359; Score: 0.44
DE  Interaction: Q9UL18; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: P09012; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: O14497; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q4U2R6; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q9Y2X3; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q9Y2T7; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q9UQ35; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q9H4B7; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q9BWF3; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q9BVA1; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q9BU76; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q9BPZ3; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q99700; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q96MR6; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q96EK7; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q92925; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q92784; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q92734; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q8WUZ0; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q8NFD5; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q8N5F7; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q6PKG0; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q4VC05; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q15020; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q13838; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q13283; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q13243; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q12926; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q07955; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: P82664; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: P51531; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: P51532; IntAct: EBI-16813719; Score: 0.35
DE  Interaction: Q9BQE3; IntAct: EBI-16814752; Score: 0.53
DE  Interaction: Q7L014; IntAct: EBI-16814752; Score: 0.35
DE  Interaction: Q13772; IntAct: EBI-16814752; Score: 0.35
DE  Interaction: P48668; IntAct: EBI-16814752; Score: 0.35
DE  Interaction: Q969F8; IntAct: EBI-21282024; Score: 0.40
DE  Interaction: Q71UM5; IntAct: EBI-25479285; Score: 0.35
DE  Interaction: P50502; IntAct: EBI-25479285; Score: 0.35
DE  Interaction: Q9Y6H1; IntAct: EBI-25479285; Score: 0.35
DE  Interaction: P40763; IntAct: EBI-25485488; Score: 0.40
DE  Interaction: Q59H18; IntAct: EBI-28941654; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005654;
GO  GO:0048471;
GO  GO:0016706;
GO  GO:0071532;
GO  GO:0031406;
GO  GO:0008198;
GO  GO:0102113;
GO  GO:0051059;
GO  GO:0005112;
GO  GO:0019826;
GO  GO:0036140;
GO  GO:0036139;
GO  GO:0042803;
GO  GO:0008270;
GO  GO:0045746;
GO  GO:0061428;
GO  GO:0042265;
GO  GO:0042264;
GO  GO:0036138;
GO  GO:0045663;
GO  GO:2001214;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEY
SQ  LQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVM
SQ  DFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS
SQ  QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMR
SQ  NIEKMLGEALGNPQEVGPLLNTMIKGRYN
//