ID  Q9NZ50;
PN  Gamma-synuclein;
GN  SNCG;
OS  9913;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11746666}. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
DR  UNIPROT: Q9NZ50;
DR  UNIPROT: Q1RMG7;
DR  UNIPROT: Q9N187;
DR  Pfam: PF01387;
DE  Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0043679;
GO  GO:0005737;
GO  GO:0005815;
GO  GO:0043025;
GO  GO:0048471;
GO  GO:0005819;
GO  GO:1903136;
GO  GO:0007268;
GO  GO:1901214;
GO  GO:0007165;
GO  GO:0050808;
GO  GO:0048488;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKEGVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATK
SQ  TVEEVENIAVTSGVVHKEALKQPVPSQEDEAAKAEEQVAEETKSGGD
//