ID  Q9NZU1;
PN  Leucine-rich repeat transmembrane protein FLRT1;
GN  FLRT1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000250|UniProtKB:Q6RKD8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q6RKD8}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6RKD8}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6RKD8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6RKD8}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q6RKD8}. Secreted {ECO:0000250|UniProtKB:Q6RKD8}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q6RKD8}. Cell junction {ECO:0000250|UniProtKB:Q6RKD8}. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:Q6RKD8}.
DR  UNIPROT: Q9NZU1;
DR  UNIPROT: Q8WVA2;
DR  Pfam: PF13855;
DR  Pfam: PF01462;
DR  PROSITE: PS50853;
DR  PROSITE: PS51450;
DR  OMIM: 604806;
DR  DisGeNET: 23769;
DE  Function: Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3. {ECO:0000250|UniProtKB:Q6RKD8}.
DE  Reference Proteome: Yes;
DE  Interaction: Q70AK3; IntAct: EBI-8042356; Score: 0.40
DE  Interaction: O43155; IntAct: EBI-8042606; Score: 0.27
DE  Interaction: Q9UN70; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: Q9NZU0; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: Q9HAR2; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: Q9H2G9; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: Q96JH8; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: Q92569; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: P42338; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: P42336; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: P27986; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: O95490; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: O94910; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: O60245; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: O14917; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: O00459; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: A6NFQ2; IntAct: EBI-21556493; Score: 0.35
DE  Interaction: Q9HC97; IntAct: EBI-20807418; Score: 0.37
DE  Interaction: P05067; IntAct: EBI-20768351; Score: 0.40
GO  GO:0005911;
GO  GO:0031410;
GO  GO:0030659;
GO  GO:0005789;
GO  GO:0031012;
GO  GO:0005615;
GO  GO:0005925;
GO  GO:0005887;
GO  GO:0044306;
GO  GO:0032809;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0030674;
GO  GO:0007155;
GO  GO:0016358;
GO  GO:0008543;
GO  GO:1990138;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNV
SQ  QVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNH
SQ  LSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLP
SQ  SAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAA
SQ  VVNVRGLMCQGPEKVRGMAIKDITSEMDECFETGPQGGVANAAAKTTASNHASATTPQGSLFTLKAKRPGLRLPDSNIDY
SQ  PMATGDGAKTLAIHVKALTADSIRITWKATLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMV
SQ  TMETSNAYVADETPVCAKAETADSYGPTTTLNQEQNAGPMASLPLAGIIGGAVALVFLFLVLGAICWYVHQAGELLTRER
SQ  AYNRGSRKKDDYMESGTKKDNSILEIRGPGLQMLPINPYRAKEEYVVHTIFPSNGSSLCKATHTIGYGTTRGYRDGGIPD
SQ  IDYSYT
//