ID  Q9QXQ0;
PN  Alpha-actinin-4;
GN  Actn4;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000250|UniProtKB:O43707}. Cytoplasm {ECO:0000250|UniProtKB:O43707}. Cell junction {ECO:0000250|UniProtKB:P57780}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:O43707}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P57780}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). {ECO:0000250|UniProtKB:O43707, ECO:0000250|UniProtKB:P57780}.
DR  UNIPROT: Q9QXQ0;
DR  UNIPROT: Q6P786;
DR  Pfam: PF00307;
DR  Pfam: PF08726;
DR  Pfam: PF00435;
DR  PROSITE: PS00019;
DR  PROSITE: PS00020;
DR  PROSITE: PS50021;
DR  PROSITE: PS00018;
DR  PROSITE: PS50222;
DE  Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. {ECO:0000250|UniProtKB:O43707}.
DE  Reference Proteome: Yes;
DE  Interaction: P19357; IntAct: EBI-921030; Score: 0.54
DE  Interaction: P21708; IntAct: EBI-7617257; Score: 0.35
DE  Interaction: P54645; IntAct: EBI-16399805; Score: 0.35
DE  Interaction: P80386; IntAct: EBI-16400563; Score: 0.35
GO  GO:0015629;
GO  GO:0030054;
GO  GO:0042995;
GO  GO:0005911;
GO  GO:0030864;
GO  GO:0030863;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005925;
GO  GO:0043005;
GO  GO:0016604;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0032991;
GO  GO:0031143;
GO  GO:1990904;
GO  GO:0001725;
GO  GO:0030018;
GO  GO:0051015;
GO  GO:0005509;
GO  GO:0031490;
GO  GO:0016922;
GO  GO:0030374;
GO  GO:0042974;
GO  GO:0001882;
GO  GO:0042803;
GO  GO:0047485;
GO  GO:0044877;
GO  GO:0000977;
GO  GO:0003713;
GO  GO:0044325;
GO  GO:0030036;
GO  GO:0051017;
GO  GO:0070830;
GO  GO:0055001;
GO  GO:1900025;
GO  GO:0035357;
GO  GO:0030335;
GO  GO:1901224;
GO  GO:0048549;
GO  GO:1902396;
GO  GO:0015031;
GO  GO:0042981;
GO  GO:1903506;
GO  GO:0001666;
GO  GO:0048384;
GO  GO:0033209;
GO  GO:0030050;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MVDYHAANQAYQYGPSSGGNGTGGGGGMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRD
SQ  GLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV
SQ  EETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM
SQ  LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRV
SQ  PQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQAEKGYEEW
SQ  LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL
SQ  NELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTI
SQ  EEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTSVTPQIINSKWEKVQQLVPKRDHALLEE
SQ  QSKQQSNEHLRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF
SQ  DNKHTNYTMEHLRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYD
SQ  VENDRQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCI
SQ  ARMAPYQGPDAAPGALDYKSFSTALYGESDL
//