ID  Q9QYG0;
PN  Protein NDRG2;
GN  Ndrg2;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:14985363, ECO:0000269|PubMed:16520977}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.
DR  UNIPROT: Q9QYG0;
DR  UNIPROT: Q3TI48;
DR  UNIPROT: Q3TY42;
DR  UNIPROT: Q3U3T5;
DR  UNIPROT: Q69ZN2;
DR  UNIPROT: Q8C661;
DR  PDB: 2QMQ;
DR  Pfam: PF03096;
DE  Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: P51637; IntAct: EBI-20565496; Score: 0.35
DE  Interaction: A2AKD7; IntAct: EBI-20566393; Score: 0.35
GO  GO:0005737;
GO  GO:0098978;
GO  GO:0005794;
GO  GO:0030426;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0030154;
GO  GO:0001818;
GO  GO:0070373;
GO  GO:1904706;
GO  GO:0007399;
GO  GO:0099173;
GO  GO:0090361;
GO  GO:0010574;
GO  GO:0007165;
GO  GO:1990874;
GO  GO:0016055;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAELQEVQITEEKPLLPGQTPETAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQ
SQ  PLFRFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHP
SQ  DTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPDMILGHLFSQEELSGNSELIQKYRGIIQHAPNLENIELYWNSYNNR
SQ  RDLNFERGGETTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASS
SQ  CMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC
//