ID  Q9QZ85;
PN  Interferon-inducible GTPase 1;
GN  Iigp1;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Parasitophorous vacuole membrane. Note=Localizes to the bacterial inclusions formed following C.trachomatis infection. Accumulates in a GTP-bound form on the parasitophorous vacuole membranes formed following T.gondii infection but exists in a GDP-bound form in uninfected cells.
DR  UNIPROT: Q9QZ85;
DR  UNIPROT: Q9Z1M3;
DR  PDB: 1TPZ;
DR  PDB: 1TQ2;
DR  PDB: 1TQ4;
DR  PDB: 1TQ6;
DR  PDB: 1TQD;
DR  PDB: 4LV5;
DR  PDB: 4LV8;
DR  PDB: 5FPH;
DR  Pfam: PF05049;
DR  PROSITE: PS51716;
DE  Function: GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction. {ECO:0000269|PubMed:11907101, ECO:0000269|PubMed:12732635, ECO:0000269|PubMed:16304607, ECO:0000269|PubMed:19242543}.
DE  Reference Proteome: Yes;
DE  Interaction: Q6P542; IntAct: EBI-6909752; Score: 0.35
DE  Interaction: A1E140; IntAct: EBI-15902276; Score: 0.54
DE  Interaction: Q9QZ85; IntAct: EBI-15902301; Score: 0.54
GO  GO:0005737;
GO  GO:0005789;
GO  GO:0032580;
GO  GO:0031965;
GO  GO:0020005;
GO  GO:0019003;
GO  GO:0005525;
GO  GO:0003924;
GO  GO:0042802;
GO  GO:0035458;
GO  GO:0019221;
GO  GO:0006952;
GO  GO:0050829;
GO  GO:0042832;
GO  GO:0045087;
GO  GO:0010506;
GO  GO:0009617;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Curator Inference {ECO:0000305};
SQ  MGQLFSSPKSDENNDLPSSFTGYFKKFNTGRKIISQEILNLIELRMRKGNIQLTNSAISDALKEIDSSVLNVAVTGETGS
SQ  GKSSFINTLRGIGNEEEGAAKTGVVEVTMERHPYKHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRF
SQ  KKNDIDIAKAISMMKKEFYFVRTKVDSDITNEADGKPQTFDKEKVLQDIRLNCVNTFRENGIAEPPIFLLSNKNVCHYDF
SQ  PVLMDKLISDLPIYKRHNFMVSLPNITDSVIEKKRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYRTVF
SQ  GVDETSLQRLARDWEIEVDQVEAMIKSPAVFKPTDEETIQERLSRYIQEFCLANGYLLPKNSFLKEIFYLKYYFLDMVTE
SQ  DAKTLLKEICLRN
//