ID  Q9R237;
PN  C-Jun-amino-terminal kinase-interacting protein 1;
GN  Mapk8ip1;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus. Endoplasmic reticulum membrane {ECO:0000250}. Mitochondrion membrane {ECO:0000250}. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus.
DR  UNIPROT: Q9R237;
DR  UNIPROT: B0VXR5;
DR  UNIPROT: O88979;
DR  UNIPROT: Q9R1H8;
DR  UNIPROT: Q9WVI5;
DR  UNIPROT: Q9WVI6;
DR  PDB: 2FPD;
DR  PDB: 2FPE;
DR  PDB: 2FPF;
DR  Pfam: PF00640;
DR  Pfam: PF14604;
DR  PROSITE: PS01179;
DR  PROSITE: PS50002;
DE  Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9, ECO:0000269|PubMed:21076496}.
DE  Reference Proteome: Yes;
DE  Interaction: P49185; IntAct: EBI-7936738; Score: 0.40
DE  Interaction: P47196; IntAct: EBI-7936797; Score: 0.40
DE  Interaction: Q9R237; IntAct: EBI-8051903; Score: 0.67
DE  Interaction: G3V9M2; IntAct: EBI-8052000; Score: 0.40
DE  Interaction: Q16584; IntAct: EBI-8052429; Score: 0.40
DE  Interaction: P45983; IntAct: EBI-8052446; Score: 0.40
DE  Interaction: O14733; IntAct: EBI-8052475; Score: 0.40
GO  GO:0030424;
GO  GO:0044295;
GO  GO:0044297;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0044294;
GO  GO:0044302;
GO  GO:0005789;
GO  GO:0016020;
GO  GO:0031966;
GO  GO:0043005;
GO  GO:0043025;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0045202;
GO  GO:0042802;
GO  GO:0008432;
GO  GO:0019894;
GO  GO:0005078;
GO  GO:0031434;
GO  GO:0031435;
GO  GO:0019901;
GO  GO:0007258;
GO  GO:0043066;
GO  GO:2001243;
GO  GO:0046329;
GO  GO:0043508;
GO  GO:0046330;
GO  GO:2000564;
GO  GO:0006355;
GO  GO:0046328;
GO  GO:0007165;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAERESGLSGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGSS
SQ  GSAGSRLQAEMLQMDLIDAASDTPGAEDDEEDDDELAAQRPGVGPSKAESGQEPASRSQGQGQGPGTGSGDTYRPKRPTT
SQ  LNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGSPVPTQDRGTSTDSPCRRTAAT
SQ  QMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDPAEPTSTFLPPTESRMSVSSDPDPAAYSVTAG
SQ  RPHPSISEEDEGFDCLSSPEQAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDY
SQ  SDESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCV
SQ  INGEEHEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDW
SQ  IDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADEAQEAKGNKCSHFFQLKN
SQ  ISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
//