ID  Q9TVM2;
PN  Exportin-1;
GN  emb;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus {ECO:0000269|PubMed:17032737}. Nucleus membrane {ECO:0000269|PubMed:17032737}; Peripheral membrane protein; Nucleoplasmic side. Note=Localization to the nuclear pore complex is promoted by Nup214. {ECO:0000269|PubMed:17032737}.
DR  UNIPROT: Q9TVM2;
DR  UNIPROT: Q9I7N7;
DR  UNIPROT: Q9U699;
DR  Pfam: PF08767;
DR  Pfam: PF18777;
DR  Pfam: PF18784;
DR  Pfam: PF18787;
DR  Pfam: PF03810;
DR  Pfam: PF08389;
DR  PROSITE: PS50166;
DE  Function: Receptor for the leucine-rich nuclear export signal (NES) (PubMed:10636888, PubMed:14638854, PubMed:16103875). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form (PubMed:10636888, PubMed:14638854). Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm (PubMed:14638854, PubMed:25858587, PubMed:17032737). Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae (PubMed:31626769). Required for the function or maintenance of certain tissues such as brain and gut (PubMed:10924475). {ECO:0000269|PubMed:10636888, ECO:0000269|PubMed:10924475, ECO:0000269|PubMed:14638854, ECO:0000269|PubMed:17032737, ECO:0000269|PubMed:25858587, ECO:0000269|PubMed:31626769}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9VTM1; IntAct: EBI-229756; Score: 0.00
DE  Interaction: Q7KML2; IntAct: EBI-229764; Score: 0.00
DE  Interaction: P22469; IntAct: EBI-7377453; Score: 0.40
DE  Interaction: Q8IRE7; IntAct: EBI-9930581; Score: 0.35
DE  Interaction: Q9VRP5; IntAct: EBI-9931195; Score: 0.35
DE  Interaction: Q9W258; IntAct: EBI-9932835; Score: 0.46
DE  Interaction: M9NFI9; IntAct: EBI-9933573; Score: 0.35
DE  Interaction: Q7KN04; IntAct: EBI-9936955; Score: 0.35
DE  Interaction: O61307; IntAct: EBI-9952935; Score: 0.35
DE  Interaction: Q9VLS7; IntAct: EBI-9954110; Score: 0.35
DE  Interaction: Q24114; IntAct: EBI-9957759; Score: 0.35
DE  Interaction: P13709; IntAct: EBI-9958960; Score: 0.35
DE  Interaction: Q0KHS0; IntAct: EBI-9959651; Score: 0.35
GO  GO:0005737;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0005634;
GO  GO:0005049;
GO  GO:0031267;
GO  GO:0007099;
GO  GO:0051028;
GO  GO:0051168;
GO  GO:0051292;
GO  GO:0006611;
GO  GO:0015031;
GO  GO:1900037;
GO  GO:0000055;
GO  GO:0000056;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MATMLTSDEAGKLLDFSQKLDINLLDKIVEVVYTAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYSQNQRTKFYALQIL
SQ  EEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKLNMILVHILKREWPRNWETFISDIVGASKTNESL
SQ  CMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCSEFSQIFTLCSFVLENSMNAALIHVTLETLLRFLNWIPLGYIFE
SQ  TQQIETLIFKFLSVPMFRNVTLKCLSEIAGLTAANYDENFATLFKDTMVQLEQIVGQNMNMNHVFKHGSDTEQELVLNLA
SQ  MFLCTFLKEHGKLVEDAKYVDYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNSEFFHPTLESTKRQQVYPRRRF
SQ  YAPILSKVRFIMISRMAKPEEVLVVENENGEVVREFMKDTNSINLYKNMRETLVFLTHLDSVDTDRIMTLKLLNQVNGSE
SQ  FSWKNLNTLCWAIGSISGAFCEEDEKRFLVTVIKDLLGLCEQKKGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNK
SQ  LFEFMHETHDGVQDMACDTFIKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMISAQVDQV
SQ  QQDVLIERYMQLPNQVWDDIISRASKNVDFLKNMTAVKQLGSILKTNVAACKALGHAYVIQLGRIYLDMLNVYKITSENI
SQ  IQAIEVNGVNVNNQPLIKTMHVVKKETLNLISEWVSRSNDNQLVMDNFIPPLLDAILLDYQRCKVPSAREPKVLSAMAII
SQ  VHKLRQHITNEVPKIFDAVFECTLDMINKNFEDFPQHRLSFYELLQAVNAHCFKAFLNIPPAQFKLVFDSVVWAFKHTMR
SQ  NVADMGLNILFKMLQNLDQHPGAAQSFYQTYFTDILMQIFSVVTDTSHTAGLPNHAIILAYMFSLVENRKITVNLGPIPD
SQ  NMIFIQEYVASLLKSAFTHLSDNQVKVFVTGLFNLDENVQAFKEHLRDFLIQIREATGEDDSDLYLEEREAALAEEQSNK
SQ  HQMQRNIPGMLNPHELPEDMQDE
//