ID  Q9U1K1;
PN  Protein spire;
GN  spir;
OS  7227;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10744979}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10744979}. Cell membrane {ECO:0000269|PubMed:21730168}; Peripheral membrane protein {ECO:0000269|PubMed:21730168}; Cytoplasmic side {ECO:0000269|PubMed:21730168}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21730168}; Peripheral membrane protein {ECO:0000269|PubMed:21730168}; Cytoplasmic side {ECO:0000269|PubMed:21730168}. Note=Punctate spots in perinuclear region and cytoplasm. {ECO:0000269|PubMed:10744979}.
DR  UNIPROT: Q9U1K1;
DR  UNIPROT: Q5U0Z8;
DR  UNIPROT: Q8INV3;
DR  UNIPROT: Q8INV4;
DR  UNIPROT: Q8INV5;
DR  UNIPROT: Q8SXP3;
DR  UNIPROT: Q8T8P8;
DR  UNIPROT: Q9U4F0;
DR  UNIPROT: Q9U4F1;
DR  UNIPROT: Q9VIN3;
DR  UNIPROT: Q9VIN4;
DR  PDB: 3MMV;
DR  PDB: 3MN5;
DR  PDB: 3MN6;
DR  PDB: 3MN7;
DR  PDB: 3MN9;
DR  PDB: 3UE5;
DR  PDB: 4EFH;
DR  Pfam: PF16474;
DR  PROSITE: PS51377;
DR  PROSITE: PS51082;
DE  Function: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Promotes dissociation of capu from the barbed end of actin filaments. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for localization of determinants within the developing oocyte to the posterior pole and to the dorsal anterior corner. Links Rho family signaling and Jnk function to the actin cytoskeleton. {ECO:0000269|PubMed:10556052, ECO:0000269|PubMed:10744979, ECO:0000269|PubMed:15674283, ECO:0000269|PubMed:20538977, ECO:0000269|PubMed:21730168}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9VRF5; IntAct: EBI-197814; Score: 0.00
DE  Interaction: Q7K159; IntAct: EBI-197818; Score: 0.00
DE  Interaction: Q7JQ36; IntAct: EBI-197822; Score: 0.00
DE  Interaction: Q9VBN2; IntAct: EBI-197831; Score: 0.00
DE  Interaction: P92208; IntAct: EBI-871706; Score: 0.50
DE  Interaction: P08736; IntAct: EBI-197839; Score: 0.00
DE  Interaction: Q9VHS2; IntAct: EBI-197843; Score: 0.00
DE  Interaction: Q9VFP2; IntAct: EBI-197847; Score: 0.00
DE  Interaction: Q9XYZ4; IntAct: EBI-509448; Score: 0.00
DE  Interaction: P10987; IntAct: EBI-15859640; Score: 0.76
DE  Interaction: P40793; IntAct: EBI-871870; Score: 0.27
DE  Interaction: P40792; IntAct: EBI-874148; Score: 0.27
DE  Interaction: P48148; IntAct: EBI-874192; Score: 0.27
DE  Interaction: Q95RI5; IntAct: EBI-9941865; Score: 0.50
DE  Interaction: Q99323; IntAct: EBI-9942589; Score: 0.35
DE  Interaction: Q9W542; IntAct: EBI-9942822; Score: 0.35
DE  Interaction: Q9VSW1; IntAct: EBI-9943131; Score: 0.35
DE  Interaction: Q9VH81; IntAct: EBI-9948351; Score: 0.35
DE  Interaction: Q8INK3; IntAct: EBI-9964589; Score: 0.35
DE  Interaction: Q9VHP0; IntAct: EBI-9966138; Score: 0.35
DE  Interaction: Q9VZP5; IntAct: EBI-9967416; Score: 0.35
DE  Interaction: P68135; IntAct: EBI-15859700; Score: 0.81
GO  GO:0005938;
GO  GO:0005737;
GO  GO:0030659;
GO  GO:0005856;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0003779;
GO  GO:0008017;
GO  GO:0030036;
GO  GO:0051639;
GO  GO:0007015;
GO  GO:0030041;
GO  GO:0030029;
GO  GO:0045010;
GO  GO:0007304;
GO  GO:0036089;
GO  GO:0051295;
GO  GO:0048193;
GO  GO:0046907;
GO  GO:0030717;
GO  GO:0048477;
GO  GO:0040038;
GO  GO:0007315;
GO  GO:0045451;
GO  GO:0007316;
GO  GO:0015031;
GO  GO:0051493;
GO  GO:0016192;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:21730168};
SQ  MTEHQAEEQADTPPTKVKATPTPTPSGKFKDAKEDAFLSTSPDSANGDAQHKLPADQLAMSSSAHPQQAGQARPLILQAF
SQ  HRCSSPEQCVTLHDILDSFKAPLSEDQAWALIHQFAGLYHQVAVQAHTCAADYEAALPTGFELHFHRDGSVHFSGPDQLT
SQ  PKEQLQQEQIPLPPQHDVIVDQPDHSASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVSHRKIISELAEIVYTALDYNLP
SQ  EDEECQVSQELENLFNFMTADETDDDCIDEGIDEGDKRWDDESEEERNDTKELEHIIETCRNHIKTTLPENHYRAVCRAL
SQ  VTETIELRVFLQQVLNNEAGAEKLIKASESSATTQQELAKLGFNDWARFWVQVIDELRRGVRLKKSNHERTPIEYELTPY
SQ  EILMGDIRAKKYQLRKVMVNGDIPPRVKKDAHAMILEFIRSRPPLKKASDRQLGPPRMCEPSPREQLMESIRKGKELKQI
SQ  TPPEAPTLRERVLPSANSTLSRSRQRLIKVDFSKFQDDDLFYDENSISSSHSTAATHQHHPHFAEMHRCSQPKMPPYPFG
SQ  GYMVPSQARQDCRETASLMRPRRTMEPAKQVPPPEEPSFTKDEYHKFYDTALESYDLATQCESRRASLRRHTIVGCQSNL
SQ  DETHSMPPTRPESRQSDDVSKETPKRSPAEQTHPSDEGSSTSSLGPWNKSFMDKQTWMERGDDRLSVTLAEIVHIRSVMT
SQ  KAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPWGIQCKLCQRTVCAKCYTKMRIPSEHFRNVPLVLISPSLLSSPA
SQ  SSSTPSPSHHAQQAHSSSTGNIMDDQFPKSLIERLLRSESDRKTRSTVGSAPSSPKHQRSNMSTPGISVGPGASSSSAAA
SQ  TGQAVEALHDQATMSSSYSAAMRPSGVHQQQKQHYNNAMSRSMEGPRSLPVHSPAYRPLSNNSTLERKSRFSRGFNLFSS
SQ  GSHLAQTQEQKENLRGEQVTVCNDCQGLVNEITSSVKQKRSSARNRTIQNLTLDLTPVWK
//