ID  Q9U3V9;
PN  Protein xmas;
GN  xmas;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus, nucleoplasm {ECO:0000269|PubMed:28472469}. Nucleus {ECO:0000269|PubMed:29779104, ECO:0000269|Ref.7}. Nucleus membrane {ECO:0000269|PubMed:18034162, ECO:0000269|PubMed:27016737, ECO:0000269|PubMed:28472469, ECO:0000269|PubMed:33602059}; Peripheral membrane protein {ECO:0000269|PubMed:18034162, ECO:0000269|PubMed:27016737, ECO:0000269|PubMed:28472469, ECO:0000269|PubMed:33602059}. Cytoplasm {ECO:0000269|PubMed:33602059}. Note=Localizes to nuclear periphery, often in contact with the nuclear pore complex (NPC). {ECO:0000269|PubMed:18034162, ECO:0000269|PubMed:27016737}.
DR  UNIPROT: Q9U3V9;
DR  UNIPROT: A0A4D6K557;
DR  UNIPROT: C9QP61;
DR  UNIPROT: D0IQ87;
DR  UNIPROT: H1UUM5;
DR  UNIPROT: Q8IR02;
DR  UNIPROT: Q8MQS3;
DR  UNIPROT: Q9U3V8;
DR  UNIPROT: Q9VX76;
DR  Pfam: PF03399;
DR  PROSITE: PS50250;
DR  PROSITE: PS50102;
DE  Function: Involved in mRNA export and mRNA coupled transcription activation (PubMed:18034162, PubMed:27016737, PubMed:33602059). Component of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex (anchoring and mRNA export complex) which functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), thereby enabling the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:18034162, PubMed:27016737). The TREX-2/AMEX complex also functions with the transcriptional coactivator SAGA/TFTC complex, to anchor a subset of transcription sites to the nuclear pore complex basket in order to achieve efficient transcription and export of their resulting mRNAs (PubMed:18034162). Within the complex, required for localization of e(y)2 to the nuclear periphery (PubMed:18034162). {ECO:0000269|PubMed:18034162, ECO:0000269|PubMed:27016737, ECO:0000269|PubMed:33602059}.
DE  Reference Proteome: Yes;
DE  Interaction: Q7JXF5; IntAct: EBI-2554458; Score: 0.46
DE  Interaction: Q9VYX1; IntAct: EBI-2550885; Score: 0.54
GO  GO:0031965;
GO  GO:0034399;
GO  GO:0005643;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0070390;
GO  GO:0043021;
GO  GO:0003723;
GO  GO:0006406;
GO  GO:0048477;
GO  GO:0016973;
GO  GO:0045944;
GO  GO:0007283;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MAEPRPGGYNYKTLLCRNIPELFLDKYVARSHFGRFGTLVNFVLRPRRMTCTVSYASEDEAARALLDGASFQGHLFDISY
SQ  ADNETAPAQKTEEWVDPDIQAELSALQSGWRNEYGSGKPIKKPQNGSSGSGGSSMLPAIPVGPATAPVSRDRTPAQLRDL
SQ  ENMMRRPAHTSEEKFSVLDARDKLLRLNRTQHKLSGATQGHCADMCPEKERVLREFQRQVAYYELQPGSDELICHERALK
SQ  QYSRSSADQETPLPHELRNETALHMTMSYLMHEIMDISERQDPQSHMGDWFHFVWDRTRSIRKEITQQELCSLGAVKLVE
SQ  QCARFHIHCAARLVDADPSVFDSKINAENLTKCLQTLKYMYHDLRIKGVPCPKEAEFRGYIVLLNLADANFLWDIGQLPA
SQ  ELQSCPEVRQAIQFYLALQDTNFVRFFQLLADKDTSYLSACILVNYFTRLRVLGLHRLIQAYRSPRKDEVSSLPLSYIAE
SQ  LLSFASEQEAADFVQHYGLQINEAGRVVLSRMHTVETEYKLPRQYELVEVKRVKSVGEVVSGEPLPPRDLYLNHRPHNSF
SQ  DDYGMLKSIAWTAKDQLAGMQQEEMQPQMPSQPPAVSKHSDTLFKVPMQPDGTAAGFGVFAAAAVPPASSIDGFSFVLPK
SQ  SRAQEFQEQAPATQQRRAQEEAKHQALQVAIAAAKKREAELMAIHEAKVAEAERVRQQKLRERQEQQRRQQQELEEQRQR
SQ  EQEKLQLEKERQLKLEQLFFVQQQEREAHKQTRTLELYQEIFQDTLAEICQSEFMSHSRACRSYESMLDSITRDLVERQM
SQ  EQSIYELGVMRVCIRRWRKYRRTQQEKDTLFNQLPLSFGAENPEGVVNKRSMEDSLRLSRRYRLGEPCDYGKLLAGLEEH
SQ  SWLKLDLWHVLDKCLPVAQPGARRFYKLLISLSGGQEGLQLNCDLDRGLLQQPQSPDARFVDGGYIRGFSQGIGLSVMKI
SQ  RDDDHDWKATDLAEANGIICLIGLDDIRLLPDRLKPLLQASRCHDVAVIVQHPANTAFVQPDIPLQELCLRSFNIFRLRK
SQ  SGNNRQRLMIALESAVKFLAKATERKRVGHLHQVETREYLLVNLGSELFRRLKYAAEHDTAIRSDTQLNPQRCVDLFNEA
SQ  VHRLQLVAGEDLSDWPQFPEELRVFVQPLPIESSLNTNRLEHFEPGWHLPERRQRIVQLLERCKLPKMPVLPRSSSLAEA
SQ  QCQWVLDYAQISQQEDCVEQIALQAIKILQYDTDDYLNFVEYLAGERMQYILRQERNPPQGIVYNTKTLKRRFLSAWYYE
SQ  FREPQIYEPVPAEENAQMLEKQPSSQAEVQQLDFDEITSKAEAVLKRFHQRQDERHTLRELNRSHKSRKRRDASDHKHAM
SQ  SSLVSALKAARSDYQGKSSAVCRLVAQMVEADQVKYQWTPNLTSLIDRKDASTRHQWRPHVNHSTRHARKLPVQSISFLS
SQ  RCLAKKGEHAGLTSCVLSVKTRYAPKTLHGRELLIWRQSSMRPLLLPSSNLWTGVLSKRHYVPRLRPAEEDEEVERRAVP
SQ  QLRITKEQSEEEEHQLQRRKDGSRLRNECSEFYLPMGEQDYSEREEENRGHRQAYVPSELMTPELATKWQTTSVTDRDRQ
SQ  LLNLEQQMKTQPSVRMTTQTWFSGNHRRYRSRRSGAKRYHVVSELEGWRRSSNHQPVPVFQGQPGEQEHLRHASHKASAR
SQ  SMPDGQERCQMVWEQKKRSPWHRTEVTNSNKVRMPRIRAAKSAVMMAQEARNKHHRLITKKLVYRPRRTVNAVQAEETED
SQ  QDTHHRHHGGGQKMSKRAPERALLKQHLADLLAVSKPEDSFRIGYQPNAPTRQLLEQGKCYVSLRREQFIHLHPVRPNSL
SQ  ILAVNLEVKESPRQPVTTLHRRDGAKRPRLVEDVVKPSLITVIRQSAATWDHNGRKVPAKKSNLVGMPSKEHAYQRRLVR
SQ  NTSTLEAIVKAQAKPRSEPKSPSSATDYHRVASQKLPHVTSKADISKAADPFKDLDKPRIKEKEVASSWKQAYVVRSKMY
SQ  DAITPYRRRAYPGKKCITKDKTDGYFLAKRSSAAAAGSSKKVKPPKQPVVSPKVQVPSVLHKKKSRESLGPQTTKTGKL
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