ID  Q9UBB4;
PN  Ataxin-10;
GN  ATXN10;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16498633}.
DR  UNIPROT: Q9UBB4;
DR  UNIPROT: A6NLC4;
DR  UNIPROT: B4DG05;
DR  UNIPROT: O14998;
DR  UNIPROT: O15009;
DR  UNIPROT: Q6I9X4;
DR  Pfam: PF09759;
DR  OMIM: 603516;
DR  OMIM: 611150;
DR  DisGeNET: 25814;
DE  Function: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. {ECO:0000250}.
DE  Disease: Spinocerebellar ataxia 10 (SCA10) [MIM:603516]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA). {ECO:0000269|PubMed:11017075}. Note=The disease is caused by variants affecting the gene represented in this entry. Note=Defects in ATXN1 may be a cause of nephronophthisis a chronic tubulo-interstitial nephropathy that leads to anemia, polyuria, polydipsia, isosthenuria and death in uremia. {ECO:0000269|PubMed:21565611}.
DE  Reference Proteome: Yes;
DE  Interaction: P00533; IntAct: EBI-702075; Score: 0.35
DE  Interaction: Q14693; IntAct: EBI-25917615; Score: 0.56
DE  Interaction: Q15049; IntAct: EBI-25917631; Score: 0.56
DE  Interaction: Q99IB8; IntAct: EBI-11613941; Score: 0.35
DE  Interaction: O75365; IntAct: EBI-1060045; Score: 0.00
DE  Interaction: Q9Y5J5; IntAct: EBI-1060584; Score: 0.00
DE  Interaction: Q9BUV8; IntAct: EBI-1061278; Score: 0.00
DE  Interaction: P43360; IntAct: EBI-1067847; Score: 0.00
DE  Interaction: Q13418; IntAct: EBI-1068425; Score: 0.00
DE  Interaction: Q9Y6J8; IntAct: EBI-1071021; Score: 0.00
DE  Interaction: P35613; IntAct: EBI-1071495; Score: 0.00
DE  Interaction: Q9Y5V3; IntAct: EBI-1075883; Score: 0.00
DE  Interaction: Q92956; IntAct: EBI-1076016; Score: 0.00
DE  Interaction: Q99623; IntAct: EBI-1079000; Score: 0.00
DE  Interaction: Q9Y2Q3; IntAct: EBI-1079777; Score: 0.00
DE  Interaction: Q9P2S5; IntAct: EBI-1079870; Score: 0.00
DE  Interaction: O00422; IntAct: EBI-1083812; Score: 0.00
DE  Interaction: P48059; IntAct: EBI-5660392; Score: 0.00
DE  Interaction: P05919; IntAct: EBI-6175288; Score: 0.46
DE  Interaction: Q77M19; IntAct: EBI-6270503; Score: 0.35
DE  Interaction: Q13618; IntAct: EBI-21329068; Score: 0.35
DE  Interaction: P04792; IntAct: EBI-6870186; Score: 0.37
DE  Interaction: Q16666; IntAct: EBI-9995438; Score: 0.35
DE  Interaction: Q9Z1B5; IntAct: EBI-10996176; Score: 0.35
DE  Interaction: Q8BFY9; IntAct: EBI-11018381; Score: 0.35
DE  Interaction: P49459; IntAct: EBI-11040518; Score: 0.35
DE  Interaction: P83887; IntAct: EBI-11057297; Score: 0.35
DE  Interaction: Q9D1H7; IntAct: EBI-11064973; Score: 0.35
DE  Interaction: P01106; IntAct: EBI-11105437; Score: 0.67
DE  Interaction: Q13751; IntAct: EBI-11135011; Score: 0.35
DE  Interaction: Q9BQE3; IntAct: EBI-11139064; Score: 0.35
DE  Interaction: Q6ZU80; IntAct: EBI-11370150; Score: 0.27
DE  Interaction: Q96NL6; IntAct: EBI-11376636; Score: 0.27
DE  Interaction: O94986; IntAct: EBI-11381405; Score: 0.27
DE  Interaction: Q5TB80; IntAct: EBI-11385924; Score: 0.27
DE  Interaction: Q9HC77; IntAct: EBI-11397411; Score: 0.27
DE  Interaction: Q9WMX2; IntAct: EBI-11513409; Score: 0.35
DE  Interaction: P27105; IntAct: EBI-12452286; Score: 0.51
DE  Interaction: P03452; IntAct: EBI-12577294; Score: 0.35
DE  Interaction: P03485; IntAct: EBI-12577388; Score: 0.35
DE  Interaction: P06821; IntAct: EBI-12577493; Score: 0.35
DE  Interaction: P03468; IntAct: EBI-12577881; Score: 0.35
DE  Interaction: Q6DPW5; IntAct: EBI-12582145; Score: 0.35
DE  Interaction: I6T1Z2; IntAct: EBI-12581941; Score: 0.35
DE  Interaction: C5E519; IntAct: EBI-12583021; Score: 0.35
DE  Interaction: C5E526; IntAct: EBI-12584981; Score: 0.35
DE  Interaction: C5E527; IntAct: EBI-12585279; Score: 0.35
DE  Interaction: Q20MH8; IntAct: EBI-12586007; Score: 0.35
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: F5HFG5; IntAct: EBI-14063444; Score: 0.35
DE  Interaction: P11142; IntAct: EBI-16794405; Score: 0.42
DE  Interaction: P09622; IntAct: EBI-20304669; Score: 0.35
DE  Interaction: P46013; IntAct: EBI-20562326; Score: 0.35
DE  Interaction: P50406; IntAct: EBI-20809027; Score: 0.37
DE  Interaction: P35408; IntAct: EBI-20811409; Score: 0.37
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: P05067; IntAct: EBI-21132308; Score: 0.35
DE  Interaction: Q9NRI5; IntAct: EBI-21376713; Score: 0.00
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: Q969R5; IntAct: EBI-25480413; Score: 0.35
DE  Interaction: P69479; IntAct: EBI-25568051; Score: 0.35
DE  Interaction: Q9C0B5; IntAct: EBI-25636144; Score: 0.35
DE  Interaction: P19739; IntAct: EBI-25685423; Score: 0.35
DE  Interaction: Q5EP34; IntAct: EBI-25773054; Score: 0.35
DE  Interaction: P63010; IntAct: EBI-25917448; Score: 0.56
DE  Interaction: O75925; IntAct: EBI-25917565; Score: 0.56
DE  Interaction: Q9BZZ5; IntAct: EBI-25917557; Score: 0.56
DE  Interaction: Q9UNS2; IntAct: EBI-25917549; Score: 0.56
DE  Interaction: Q96E88; IntAct: EBI-25917541; Score: 0.56
DE  Interaction: Q13772; IntAct: EBI-25917531; Score: 0.56
DE  Interaction: Q9UNY5; IntAct: EBI-25917523; Score: 0.56
DE  Interaction: Q16611; IntAct: EBI-25917456; Score: 0.56
DE  Interaction: Q04724; IntAct: EBI-25917507; Score: 0.56
DE  Interaction: O14974; IntAct: EBI-25917499; Score: 0.56
DE  Interaction: P55198; IntAct: EBI-25917481; Score: 0.56
DE  Interaction: P61978; IntAct: EBI-25917473; Score: 0.56
DE  Interaction: P29017; IntAct: EBI-25917464; Score: 0.56
DE  Interaction: P08670; IntAct: EBI-25917515; Score: 0.56
DE  Interaction: Q12891; IntAct: EBI-25917573; Score: 0.56
DE  Interaction: Q6NX45; IntAct: EBI-25917763; Score: 0.56
DE  Interaction: Q7Z7K6; IntAct: EBI-25917755; Score: 0.56
DE  Interaction: Q8N6K7; IntAct: EBI-25917747; Score: 0.56
DE  Interaction: Q96KN4; IntAct: EBI-25917739; Score: 0.56
DE  Interaction: Q2TBE0; IntAct: EBI-25917729; Score: 0.56
DE  Interaction: Q8IYU4; IntAct: EBI-25917719; Score: 0.56
DE  Interaction: Q71DI3; IntAct: EBI-25917711; Score: 0.56
DE  Interaction: Q8IUW3; IntAct: EBI-25917703; Score: 0.56
DE  Interaction: Q8WVJ9; IntAct: EBI-25917695; Score: 0.56
DE  Interaction: Q8NHS9; IntAct: EBI-25917687; Score: 0.56
DE  Interaction: Q9GZS3; IntAct: EBI-25917679; Score: 0.56
DE  Interaction: Q9H347; IntAct: EBI-25917671; Score: 0.56
DE  Interaction: Q9UHD9; IntAct: EBI-25917663; Score: 0.56
DE  Interaction: Q5T6S3; IntAct: EBI-25917655; Score: 0.56
DE  Interaction: Q9BR01; IntAct: EBI-25917647; Score: 0.56
DE  Interaction: Q9Y2L8; IntAct: EBI-25917639; Score: 0.56
DE  Interaction: Q14689; IntAct: EBI-25917623; Score: 0.56
DE  Interaction: Q9BVJ6; IntAct: EBI-25917607; Score: 0.56
DE  Interaction: O95391; IntAct: EBI-25917599; Score: 0.56
DE  Interaction: O94851; IntAct: EBI-25917591; Score: 0.56
DE  Interaction: Q9UJX2; IntAct: EBI-25917581; Score: 0.56
DE  Interaction: Q8NCK7; IntAct: EBI-27103180; Score: 0.35
DE  Interaction: Q8NCE2; IntAct: EBI-27113554; Score: 0.35
DE  Interaction: P23771; IntAct: EBI-29000509; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0005615;
GO  GO:0016020;
GO  GO:0043025;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0060271;
GO  GO:0007399;
GO  GO:0031175;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQL
SQ  ITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPE
SQ  LFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNN
SQ  QERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELL
SQ  GYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPL
SQ  ILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP
//