ID  Q9UBF8;
PN  Phosphatidylinositol 4-kinase beta;
GN  PI4KB;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus {ECO:0000269|PubMed:22124328}. Golgi apparatus membrane {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5- bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207). GGA2 is also involved in the recruitment (PubMed:28289207). {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}.
DR  UNIPROT: Q9UBF8;
DR  UNIPROT: B4DGI2;
DR  UNIPROT: O15096;
DR  UNIPROT: P78405;
DR  UNIPROT: Q5VWB9;
DR  UNIPROT: Q5VWC0;
DR  UNIPROT: Q5VWC1;
DR  UNIPROT: Q9BWR6;
DR  PDB: 2N73;
DR  PDB: 4D0L;
DR  PDB: 4D0M;
DR  PDB: 4WAE;
DR  PDB: 4WAG;
DR  PDB: 5C46;
DR  PDB: 5C4G;
DR  PDB: 5EUQ;
DR  PDB: 5FBL;
DR  PDB: 5FBQ;
DR  PDB: 5FBR;
DR  PDB: 5FBV;
DR  PDB: 5FBW;
DR  PDB: 5LX2;
DR  PDB: 5NAS;
DR  PDB: 6GL3;
DR  Pfam: PF00454;
DR  PROSITE: PS00915;
DR  PROSITE: PS00916;
DR  PROSITE: PS50290;
DR  PROSITE: PS51545;
DR  OMIM: 602758;
DR  DisGeNET: 5298;
DE  Function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:9405935}. (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}.
DE  Reference Proteome: Yes;
DE  Interaction: P50613; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: P31946; IntAct: EBI-7300211; Score: 0.69
DE  Interaction: P61981; IntAct: EBI-7300335; Score: 0.69
DE  Interaction: P27348; IntAct: EBI-7300557; Score: 0.76
DE  Interaction: P31947; IntAct: EBI-7544334; Score: 0.40
DE  Interaction: Q8WVZ9; IntAct: EBI-3232144; Score: 0.35
DE  Interaction: Q9H3P7; IntAct: EBI-7587837; Score: 0.54
DE  Interaction: P17047; IntAct: EBI-9103729; Score: 0.27
DE  Interaction: P11438; IntAct: EBI-9103723; Score: 0.27
DE  Interaction: P03495; IntAct: EBI-9116831; Score: 0.51
DE  Interaction: P46939; IntAct: EBI-11070450; Score: 0.40
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: Q9Y3M2; IntAct: EBI-11936324; Score: 0.00
DE  Interaction: Q96QF0; IntAct: EBI-11936315; Score: 0.00
DE  Interaction: P06930; IntAct: EBI-26506878; Score: 0.37
DE  Interaction: Q8IXB1; IntAct: EBI-21546557; Score: 0.35
DE  Interaction: P29466; IntAct: EBI-21873638; Score: 0.35
DE  Interaction: Q8NG50; IntAct: EBI-21900783; Score: 0.35
DE  Interaction: Q04917; IntAct: EBI-21907689; Score: 0.35
DE  Interaction: P63104; IntAct: EBI-21909838; Score: 0.35
DE  Interaction: P62491; IntAct: EBI-16107859; Score: 0.68
DE  Interaction: O75154; IntAct: EBI-16107877; Score: 0.58
DE  Interaction: Q6PJG9; IntAct: EBI-21228157; Score: 0.35
DE  Interaction: O94776; IntAct: EBI-21228157; Score: 0.35
DE  Interaction: P63151; IntAct: EBI-21228157; Score: 0.35
DE  Interaction: P04062; IntAct: EBI-21228157; Score: 0.35
DE  Interaction: Q5T2E6; IntAct: EBI-21228157; Score: 0.35
DE  Interaction: P03300; IntAct: EBI-21253323; Score: 0.50
DE  Interaction: O75592; IntAct: EBI-26513164; Score: 0.37
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005768;
GO  GO:0005794;
GO  GO:0000139;
GO  GO:0016020;
GO  GO:0005741;
GO  GO:0048471;
GO  GO:0030867;
GO  GO:0004430;
GO  GO:0071889;
GO  GO:0005524;
GO  GO:0052742;
GO  GO:0007040;
GO  GO:0006661;
GO  GO:0046854;
GO  GO:0048015;
GO  GO:0016310;
GO  GO:0006898;
GO  GO:0007165;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNG
SQ  DGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYI
SQ  GNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLI
SQ  LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPV
SQ  RLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIY
SQ  VEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCD
SQ  NISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLS
SQ  VIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGS
SQ  YTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
SQ  LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSI
SQ  TTKLYDGFQYLTNGIM
//