ID  Q9UI30;
PN  Multifunctional methyltransferase subunit TRM112-like protein;
GN  TRMT112;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus, nucleoplasm {ECO:0000269|PubMed:25851604}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25851604}. Note=Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604). {ECO:0000269|PubMed:25851604}.
DR  UNIPROT: Q9UI30;
DR  UNIPROT: B2R539;
DR  UNIPROT: J3KNG5;
DR  UNIPROT: Q3MHC7;
DR  UNIPROT: Q8N2Z4;
DR  PDB: 6G4W;
DR  PDB: 6H1D;
DR  PDB: 6H1E;
DR  PDB: 6H2U;
DR  PDB: 6H2V;
DR  PDB: 6K0X;
DR  PDB: 6KHS;
DR  PDB: 6KMR;
DR  PDB: 6KMS;
DR  PDB: 6PED;
DR  Pfam: PF03966;
DR  OMIM: 618630;
DR  DisGeNET: 51504;
DE  Function: Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604, PubMed:18539146, PubMed:20308323, PubMed:25851604, PubMed:31328227, PubMed:31636962, PubMed:31061526). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S- adenosyl L-methionine as methyl donor (PubMed:18539146, PubMed:31636962, PubMed:31061526). The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1) (PubMed:31061526). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (PubMed:34669960). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604). Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:33428944, PubMed:35033535, PubMed:31328227). {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:31061526, ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:31636962, ECO:0000269|PubMed:33428944, ECO:0000269|PubMed:34669960}.
DE  Reference Proteome: Yes;
DE  Interaction: O43709; IntAct: EBI-23853163; Score: 0.83
DE  Interaction: P0DTD1; IntAct: EBI-27030072; Score: 0.35
DE  Interaction: Q92900; IntAct: EBI-374151; Score: 0.00
DE  Interaction: Q9NX70; IntAct: EBI-394875; Score: 0.35
DE  Interaction: P40337; IntAct: EBI-1064475; Score: 0.00
DE  Interaction: P62330; IntAct: EBI-1066544; Score: 0.00
DE  Interaction: Q9UKE5; IntAct: EBI-1067751; Score: 0.00
DE  Interaction: O76081; IntAct: EBI-1072646; Score: 0.00
DE  Interaction: P23508; IntAct: EBI-1072670; Score: 0.00
DE  Interaction: Q14164; IntAct: EBI-1075070; Score: 0.00
DE  Interaction: Q9Y4K3; IntAct: EBI-1076545; Score: 0.00
DE  Interaction: Q9Y478; IntAct: EBI-1078230; Score: 0.00
DE  Interaction: P01889; IntAct: EBI-1079721; Score: 0.00
DE  Interaction: P11171; IntAct: EBI-1083784; Score: 0.00
DE  Interaction: Q9Y5N5; IntAct: EBI-7966690; Score: 0.75
DE  Interaction: P04591; IntAct: EBI-6174702; Score: 0.35
DE  Interaction: Q13617; IntAct: EBI-21327106; Score: 0.35
DE  Interaction: Q38SD2; IntAct: EBI-9659564; Score: 0.44
DE  Interaction: Q96BT7; IntAct: EBI-10825679; Score: 0.79
DE  Interaction: Q6ZWV7; IntAct: EBI-10997876; Score: 0.35
DE  Interaction: P23116; IntAct: EBI-11020127; Score: 0.35
DE  Interaction: P27635; IntAct: EBI-11035646; Score: 0.35
DE  Interaction: P60710; IntAct: EBI-11045267; Score: 0.35
DE  Interaction: F8VQC1; IntAct: EBI-11054725; Score: 0.35
DE  Interaction: Q99PL5; IntAct: EBI-11066888; Score: 0.35
DE  Interaction: P06748; IntAct: EBI-11145880; Score: 0.35
DE  Interaction: P60229; IntAct: EBI-11148789; Score: 0.35
DE  Interaction: O60506; IntAct: EBI-11153302; Score: 0.35
DE  Interaction: Q6FHY5; IntAct: EBI-24325034; Score: 0.56
DE  Interaction: Q9NRN9; IntAct: EBI-24675349; Score: 0.71
DE  Interaction: Q9BV44; IntAct: EBI-24643613; Score: 0.78
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: Q8IVT5; IntAct: EBI-14035332; Score: 0.35
DE  Interaction: Q7Z4G4; IntAct: EBI-30812343; Score: 0.54
DE  Interaction: Q14684; IntAct: EBI-16686997; Score: 0.35
DE  Interaction: P15311; IntAct: EBI-16791848; Score: 0.27
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: Q8K337; IntAct: EBI-25409748; Score: 0.35
DE  Interaction: O54834; IntAct: EBI-25411200; Score: 0.35
DE  Interaction: Q9C0B5; IntAct: EBI-25636144; Score: 0.35
DE  Interaction: Q01995; IntAct: EBI-26878675; Score: 0.35
DE  Interaction: Q9BXK1; IntAct: EBI-29019783; Score: 0.35
DE  Interaction: O95600; IntAct: EBI-29020196; Score: 0.35
DE  Interaction: Q9BTF0; IntAct: EBI-30812343; Score: 0.54
GO  GO:0005829;
GO  GO:0005654;
GO  GO:0048471;
GO  GO:0032991;
GO  GO:0046982;
GO  GO:0008276;
GO  GO:0034968;
GO  GO:0018364;
GO  GO:2000234;
GO  GO:0070476;
GO  GO:0031167;
GO  GO:0030488;
GO  GO:0002940;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMIPKVEWSAFLEAADNLRLIQVPKGPVEGYEENEEF
SQ  LRTMHHLLLEVEVIEGTLQCPESGRMFPISRGIPNMLLSEEETES
//