ID  Q9UKA1;
PN  F-box/LRR-repeat protein 5;
GN  FBXL5;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17532294}.
DR  UNIPROT: Q9UKA1;
DR  UNIPROT: A8MSK4;
DR  UNIPROT: B4DIB5;
DR  UNIPROT: Q4W5A8;
DR  UNIPROT: Q8NHP3;
DR  UNIPROT: Q9NXN2;
DR  UNIPROT: Q9P0I0;
DR  UNIPROT: Q9P0X5;
DR  UNIPROT: Q9UJT7;
DR  UNIPROT: Q9UKC8;
DR  PDB: 3U9J;
DR  PDB: 3U9M;
DR  PDB: 3V5X;
DR  PDB: 3V5Y;
DR  PDB: 3V5Z;
DR  PDB: 6VCD;
DR  Pfam: PF12937;
DR  Pfam: PF01814;
DR  Pfam: PF13516;
DR  PROSITE: PS50181;
DR  OMIM: 605655;
DR  DisGeNET: 26234;
DE  Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. {ECO:0000269|PubMed:17532294, ECO:0000269|PubMed:19762596, ECO:0000269|PubMed:19762597}.
DE  Reference Proteome: Yes;
DE  Interaction: P49454; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q7L5N1; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q92905; IntAct: EBI-21325777; Score: 0.53
DE  Interaction: P10242; IntAct: EBI-2692353; Score: 0.00
DE  Interaction: Q5NID2; IntAct: EBI-2806872; Score: 0.00
DE  Interaction: P63208; IntAct: EBI-8636412; Score: 0.83
DE  Interaction: Q09472; IntAct: EBI-3937381; Score: 0.37
DE  Interaction: O43929; IntAct: EBI-3938477; Score: 0.44
DE  Interaction: P67870; IntAct: EBI-7133308; Score: 0.37
DE  Interaction: P53350; IntAct: EBI-7312743; Score: 0.37
DE  Interaction: Q9Y4X5; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q9Y3D0; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q9UNS2; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q9H2Y7; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q9BQ90; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q96T76; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q96JN8; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q92624; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q8N5M4; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q562R1; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q3KQU3; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q13616; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: P61201; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: P60709; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: P28676; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: P26232; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: O95714; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: O76071; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: O75521; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q13148; IntAct: EBI-25985913; Score: 0.56
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0019005;
GO  GO:0000151;
GO  GO:0005506;
GO  GO:0004842;
GO  GO:0055072;
GO  GO:0045732;
GO  GO:0016567;
GO  GO:0031146;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVH
SQ  SDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCS
SQ  QKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTK
SQ  TGSLWKHLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGL
SQ  IHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVA
SQ  LEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVW
SQ  MLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTM
SQ  SSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTIT
SQ  GAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE
//