ID  Q9UN36;
PN  Protein NDRG2;
GN  NDRG2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.
DR  UNIPROT: Q9UN36;
DR  UNIPROT: B3KUE3;
DR  UNIPROT: B4DE86;
DR  UNIPROT: B7WP11;
DR  UNIPROT: B7WPD5;
DR  UNIPROT: D3DS07;
DR  UNIPROT: D3DS10;
DR  UNIPROT: Q567T1;
DR  UNIPROT: Q68DW2;
DR  UNIPROT: Q86U08;
DR  UNIPROT: Q86U46;
DR  UNIPROT: Q96FD3;
DR  UNIPROT: Q96FT0;
DR  UNIPROT: Q96JU0;
DR  UNIPROT: Q96PN0;
DR  UNIPROT: Q9BQH5;
DR  UNIPROT: Q9ULH2;
DR  PDB: 2XMQ;
DR  PDB: 2XMR;
DR  PDB: 2XMS;
DR  Pfam: PF03096;
DR  OMIM: 605272;
DR  DisGeNET: 57447;
DE  Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}.
DE  Reference Proteome: Yes;
DE  Interaction: P03372; IntAct: EBI-3895740; Score: 0.53
DE  Interaction: Q9UI14; IntAct: EBI-8084498; Score: 0.61
DE  Interaction: P35222; IntAct: EBI-8084686; Score: 0.35
DE  Interaction: Q96Q40; IntAct: EBI-21574933; Score: 0.35
DE  Interaction: Q9UMR2; IntAct: EBI-21616596; Score: 0.35
DE  Interaction: Q92597; IntAct: EBI-21847586; Score: 0.35
DE  Interaction: P11142; IntAct: EBI-21847586; Score: 0.35
DE  Interaction: P30556; IntAct: EBI-20802719; Score: 0.37
DE  Interaction: P51679; IntAct: EBI-20804498; Score: 0.37
DE  Interaction: P10636; IntAct: EBI-20749487; Score: 0.35
DE  Interaction: Q92685; IntAct: EBI-25468455; Score: 0.37
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0070062;
GO  GO:0005794;
GO  GO:0030426;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0030154;
GO  GO:0001818;
GO  GO:0070373;
GO  GO:1904706;
GO  GO:0090361;
GO  GO:0010574;
GO  GO:0007165;
GO  GO:0021762;
GO  GO:1990874;
GO  GO:0016055;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQ
SQ  PLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHP
SQ  DTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNR
SQ  RDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASS
SQ  CMTRLSRSRTASLTSAASVDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC
//