ID  Q9UQF2;
PN  C-Jun-amino-terminal kinase-interacting protein 1;
GN  MAPK8IP1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.
DR  UNIPROT: Q9UQF2;
DR  UNIPROT: D3DQP4;
DR  UNIPROT: O43407;
DR  PDB: 2G01;
DR  PDB: 2GMX;
DR  PDB: 2H96;
DR  PDB: 3OXI;
DR  PDB: 3PTG;
DR  PDB: 3VUD;
DR  PDB: 3VUG;
DR  PDB: 3VUH;
DR  PDB: 3VUI;
DR  PDB: 3VUK;
DR  PDB: 3VUL;
DR  PDB: 3VUM;
DR  PDB: 4E73;
DR  PDB: 4G1W;
DR  PDB: 4H39;
DR  PDB: 4HYS;
DR  PDB: 4HYU;
DR  PDB: 4IZY;
DR  PDB: 5LW1;
DR  PDB: 6FUZ;
DR  PDB: 7NYK;
DR  PDB: 7NYL;
DR  PDB: 7NYM;
DR  PDB: 7NYN;
DR  PDB: 7NYO;
DR  PDB: 7NZB;
DR  Pfam: PF00640;
DR  Pfam: PF14604;
DR  PROSITE: PS01179;
DR  PROSITE: PS50002;
DR  OMIM: 125853;
DR  OMIM: 604641;
DR  DisGeNET: 9479;
DE  Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}.
DE  Disease: Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:10700186}. Note=The disease may be caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: P00533; IntAct: EBI-7876199; Score: 0.44
DE  Interaction: P04626; IntAct: EBI-7873480; Score: 0.59
DE  Interaction: Q86Y07; IntAct: EBI-2122041; Score: 0.46
DE  Interaction: Q9ESN9; IntAct: EBI-7017807; Score: 0.40
DE  Interaction: Q9UPT6; IntAct: EBI-21663692; Score: 0.35
DE  Interaction: P05067; IntAct: EBI-78422; Score: 0.72
DE  Interaction: P12023; IntAct: EBI-286558; Score: 0.51
DE  Interaction: P05106; IntAct: EBI-8612295; Score: 0.44
DE  Interaction: O94762; IntAct: EBI-735599; Score: 0.00
DE  Interaction: Q8CD76; IntAct: EBI-7299159; Score: 0.40
DE  Interaction: P27824; IntAct: EBI-1779262; Score: 0.27
DE  Interaction: O43318; IntAct: EBI-2121802; Score: 0.72
DE  Interaction: P45983; IntAct: EBI-2121802; Score: 0.62
DE  Interaction: O14733; IntAct: EBI-2121802; Score: 0.62
DE  Interaction: Q15750; IntAct: EBI-2121802; Score: 0.35
DE  Interaction: Q9UQF2; IntAct: EBI-2122091; Score: 0.40
DE  Interaction: P20505; IntAct: EBI-8568176; Score: 0.40
DE  Interaction: Q9UK73; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: Q7Z333; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: Q14679; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: Q13509; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: Q13387; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: Q01484; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: P45984; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: P31273; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: Q12955; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: Q96HI0; IntAct: EBI-21639159; Score: 0.35
DE  Interaction: P06241; IntAct: EBI-21392427; Score: 0.00
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0044302;
GO  GO:0005789;
GO  GO:0031966;
GO  GO:0043025;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0045202;
GO  GO:0019894;
GO  GO:0005078;
GO  GO:0019901;
GO  GO:0004860;
GO  GO:0007258;
GO  GO:2001243;
GO  GO:0043508;
GO  GO:0046330;
GO  GO:2000564;
GO  GO:0006355;
GO  GO:0046328;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGG
SQ  GGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKR
SQ  PTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRS
SQ  TATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPS
SQ  TAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCF
SQ  GDYSDESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLF
SQ  SCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKN
SQ  SDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQ
SQ  LKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
//