ID  Q9UTB5;
PN  Phosphatidylserine decarboxylase 2 alpha chain;
GN  psd2;
OS  284812;
SL  Nucleus Position: SL-0178;
SL  Comments: [Phosphatidylserine decarboxylase 2 beta chain]: Mitochondrion {ECO:0000305|PubMed:16823372, ECO:0000305|PubMed:34818062}. Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208}. Nucleus envelope {ECO:0000269|PubMed:16823372}. [Phosphatidylserine decarboxylase 2 alpha chain]: Mitochondrion {ECO:0000305|PubMed:16823372, ECO:0000305|PubMed:34818062}. Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208}. Nucleus envelope {ECO:0000269|PubMed:16823372}. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain. {ECO:0000255|HAMAP-Rule:MF_03208}. Lipid droplet {ECO:0000269|PubMed:34818062}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:34818062}.
DR  UNIPROT: Q9UTB5;
DR  Pfam: PF02666;
DE  Function: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Together with psd1 and psd3, responsible for the majority of phosphatidylethanolamine synthesis (PubMed:19286980). Plays a role in lipid droplet biogenesis at the endoplasmic reticulum membrane (PubMed:34818062). {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:19286980, ECO:0000269|PubMed:34818062}.
DE  Reference Proteome: Yes;
GO  GO:0005789;
GO  GO:0031305;
GO  GO:0005811;
GO  GO:0005739;
GO  GO:0005635;
GO  GO:0004609;
GO  GO:0140042;
GO  GO:0006656;
GO  GO:0006646;
GO  GO:0016540;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255|HAMAP-Rule:MF_03208};
SQ  MRPRQRFRRFHPRWSKVNLRGFGGVGALKGVKALNGMNVRVSMRLKWISNRIHRIRRSRRLGRLSISVRPNGSWQVYLLS
SQ  SLPLRSLSRVWGQFNRAHLPTFLRTPGFKLYAWVFGCNLSELKDPDLTHYRNFQDFFCRELRPETRPVDPVSPVVSPVDG
SQ  RIVCQGVVDNNRIQHVKGLSYSLEALLGGISSSNPLVVNFEDEITPDLIQKHEQFAEQHSISLNSNNRYRKADASAAVVD
SQ  EHSDEEALLCAFTDHPHFYLNDSRNSLNYFCPFSAFEDISNSVRSSCGKRLSPSSNFDLNNLGGDDDLRSESSSDFESAP
SQ  ASILEHEPTNWDDWVQEADVTDIDSLPWHNIRPGNKLFYSVIYLAPGDYHRFHSPADWVIESRRHFSGELFSVSPFLARR
SQ  LHNLFVLNERVALLGRYEHGFMSMIPVGATNVGSIVINCDPTLSTNRLVLRKKSLGTFQEAVYKNASPVLDGMPVSRGEQ
SQ  VGGFQLGSTVVLVFEAPADFEFSTYQGQYVRVGEAL
//