ID  Q9UUE5;
PN  Nucleoporin nup85;
GN  nup85;
OS  284812;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus envelope {ECO:0000269|PubMed:15116432, ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15226438}. Note=Localizes to the nuclear envelope and spindle pole body. {ECO:0000269|PubMed:16823372}.
DR  UNIPROT: Q9UUE5;
DR  Pfam: PF07575;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. {ECO:0000269|PubMed:15116432}.
DE  Reference Proteome: Yes;
DE  Interaction: Q10099; IntAct: EBI-1563788; Score: 0.35
DE  Interaction: Q9UTK4; IntAct: EBI-1563817; Score: 0.40
DE  Interaction: O43044; IntAct: EBI-1563722; Score: 0.40
GO  GO:0005829;
GO  GO:0000791;
GO  GO:0000792;
GO  GO:0005635;
GO  GO:0034399;
GO  GO:0005643;
GO  GO:0031080;
GO  GO:0140602;
GO  GO:0005634;
GO  GO:0005816;
GO  GO:1990188;
GO  GO:0017056;
GO  GO:0006406;
GO  GO:0045893;
GO  GO:0006606;
GO  GO:0006407;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MESSDEVDLPVYHLQNAPIENGKLNDWRSKGRTVAFKLHPFLRKGLAYINNKEFDENTLKSDKFEEVESLVYEFSTPSTL
SQ  IEPNYLLTAWHELWEELQDTYMTPILDSEANLLLLTQFYGKISSLFRSKIIQVLEELQSRINEGEKDCQPVLDSLWEVES
SQ  AWRCAEAIYFPPSSPYTLSTGILDWVNAYDPQPIADDGLEIMAYRIPYQHPEFWPYVNKTAIRGLFEQTISCLEMSGLTK
SQ  EWPVLKETVDELIDILRYSPCTHQKRIRSVSDFERRWKLWRSRLANLRHVVKKHRDIDSEVLDDFVVLLDILNGNKEVIM
SQ  LSCAHWQEYFSALAFLYGPLDCKNPEDISLLYQLATGEDSKFYVNGTIEYEQICVNLCSNEPLNAIKHAYLLDLGLAVHL
SQ  ADLLSKSGHLRDYITEEYPITLREHLILEYGQCVLESRNLWQTSFAYWKCVADSGYQRIKACIPYVPLSDVDAKETALQL
SQ  CKQLKLRDEAQLVLTHWADELIARNHYGEALIALDNAANYSALNRVTWELFDICIAEKKSFSPDKDELLYELFSSPKACT
SQ  PTLASIISPAATIHQYFFYLQHKKELNASELLVGLLTMVDFPSSRFPKLLELLHEFLNNPLQSNSTDFKLSLVNVYDCIA
SQ  VLQDQQSTVKDQQLLLSIHERLSSAISWYFLHLKK
//