ID  Q9V3H8;
PN  NTF2-related export protein;
GN  Nxt1;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus {ECO:0000269|PubMed:31384064}. Nucleus envelope {ECO:0000269|PubMed:31384064}. Note=Associates with the nuclear pore complex. {ECO:0000269|PubMed:31384064}.
DR  UNIPROT: Q9V3H8;
DR  PDB: 6IHJ;
DR  PDB: 6MRK;
DR  Pfam: PF02136;
DR  PROSITE: PS50177;
DE  Function: Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). In ovaries, plays a role in transposable element silencing regulation (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835, PubMed:33856346). Forms a complex with nxf2, Panx and piwi which acts as effector of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). In ovarian follicle cells, enables the nuclear export of flamenco (flam) transcripts and subsequent piRNA biogenesis (PubMed:33856346). {ECO:0000250|UniProtKB:Q9UKK6, ECO:0000269|PubMed:14729961, ECO:0000269|PubMed:31219034, ECO:0000269|PubMed:31368590, ECO:0000269|PubMed:31384064, ECO:0000269|PubMed:31570835, ECO:0000269|PubMed:33856346}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9U1H9; IntAct: EBI-873824; Score: 0.27
DE  Interaction: Q8IQK4; IntAct: EBI-15170706; Score: 0.49
GO  GO:0005737;
GO  GO:0005635;
GO  GO:0044613;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0017053;
GO  GO:0050829;
GO  GO:0045824;
GO  GO:0006913;
GO  GO:0016973;
GO  GO:0006606;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDSDLKAKVESCARTADTFTRLYYASVDNRRQQIGRLYLDNATLSWNGNGAIGRQMIESYFQELPSSNHQLNTLDAQPIV
SQ  DQAVSNQLAYLIMASGSVKFADQQLRKFQQTFIVTAENDKWKVVSDCYRMQEV
//