ID  Q9V463;
PN  Nuclear pore complex protein Nup154;
GN  Nup154;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:17410542}. Chromosome {ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:9732281}. Nucleus {ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:9732281}. Nucleus membrane {ECO:0000269|PubMed:17277377, ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:9732281}; Peripheral membrane protein {ECO:0000269|PubMed:17410542}; Cytoplasmic side {ECO:0000269|PubMed:17410542}. Nucleus membrane {ECO:0000269|PubMed:17277377, ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:9732281}; Peripheral membrane protein {ECO:0000269|PubMed:17410542}; Nucleoplasmic side {ECO:0000269|PubMed:17410542}. Cytoplasm {ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353}. Note=Increased localization to chromatin before interphase (PubMed:22718353). Distributed along filamentous structures that extend radially on the nuclear side of the pore complex (PubMed:17410542). {ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353}.
DR  UNIPROT: Q9V463;
DR  UNIPROT: O62536;
DR  UNIPROT: O62610;
DR  UNIPROT: O62613;
DR  UNIPROT: Q9VKL5;
DR  Pfam: PF03177;
DR  Pfam: PF08801;
DE  Function: Component of the nuclear pore complex (PubMed:17410542). Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope (PubMed:22718353). In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad (PubMed:21696798). Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:22718353, PubMed:26341556). Has a role in female fertility including egg chamber development; in nurse cells, has a role in the organization of F-actin in subcortical and cytoplasmic actin filaments important for the transfer of cytoplasm from nurse cells to the growing oocytes (PubMed:9732281, PubMed:10511559, PubMed:17410542, PubMed:17277377). Has a role in male spermatogenesis and fertility (PubMed:9732281, PubMed:10511559). Has a role in germ line cell proliferation (PubMed:21696798). {ECO:0000269|PubMed:10511559, ECO:0000269|PubMed:17277377, ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:21696798, ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:26341556, ECO:0000269|PubMed:9732281, ECO:0000303|PubMed:17410542}.
DE  Reference Proteome: Yes;
DE  Interaction: Q24568; IntAct: EBI-9919289; Score: 0.35
DE  Interaction: Q9VTU4; IntAct: EBI-274219; Score: 0.00
DE  Interaction: P92177; IntAct: EBI-8283416; Score: 0.35
DE  Interaction: P18431; IntAct: EBI-9925534; Score: 0.35
GO  GO:0005694;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0034399;
GO  GO:0005643;
GO  GO:0044611;
GO  GO:0005634;
GO  GO:0003682;
GO  GO:0017056;
GO  GO:0007015;
GO  GO:0055050;
GO  GO:0007303;
GO  GO:0001654;
GO  GO:0007281;
GO  GO:0007295;
GO  GO:0007140;
GO  GO:0051028;
GO  GO:0001555;
GO  GO:0030715;
GO  GO:0030717;
GO  GO:0048477;
GO  GO:1905938;
GO  GO:0042307;
GO  GO:1900182;
GO  GO:0006606;
GO  GO:0036228;
GO  GO:0045477;
GO  GO:1905879;
GO  GO:1905475;
GO  GO:0006405;
GO  GO:0007283;
GO  GO:0000972;
GO  GO:0035220;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:17410542};
SQ  MTLPQAQLDFFTTATSMLEWHYNLERNKPGLLELTGVSQHGRATMSGLNDYDYQSLSFLKSDRTHNLQQMRTVTKSAIPN
SQ  EILEHFKHIKCHCTMGLFPEIGRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVKYLLVLTTPI
SQ  EVIVLGVTFGESSYNEMQLMNRPVFVIGTDNVSISVIKGTDDGRIFLGGRDGCLYEIYYQAESSWFGKRCKKINLSQGLV
SQ  SYMVPSFLKVFSEVDPIEHIEIDNSRKLLYVLTEKGVIEAWDISTSYTTARRLGRITQNDITNQAVSLITTVDPSIFKSV
SQ  KAICPLSADDADKLHLVAVTQCGVRLFFSTTSLNVKQQFGPAVPCSPGENTGFGQPAVQPPLSPNAEAPKGLYLLHVRLP
SQ  PGYTPNATTNKPKQVHAAHYTEGTMLMITTQQHEQDLLWSLSSAPSVNFTYLVESTALESLDGVVWGLAEVHEPSTPQRK
SQ  SPLNSARHARKVALLTNQGTHIIEVLKMVDVLRQILLSCNGPHHEEVKMFFQSQNQREACVTALLLATSDTYRGSDVALW
SQ  AAQAFMLYGGEPCYQHQKFLNASNRNMANQTLGPNTTNVRERQSMFMSTPMPNSVANSPVGFPGSQFNQPISPIGNMQPP
SQ  QVAVSNENSPIVFSAKHDGLYMYVSRMLHSVWQMRCVNEQFCSNLSQSECALLLSDLRSLRSFLEVHSVHDISSTTRVSF
SQ  DNHLDRTNSYNTIMMGNTLLPIPEQRVLSEQAQVEETRSLSALNLFVKHACEVISLWNILNSHSFQLICVQLSPEHQKLL
SQ  TCSTFRDLLITRSEVCAFLIISLINLYLKDAAGVSEVSKNLRENCPNLYRHEDDVTYKATELLMNAKNCTSATEKEHMLR
SQ  TTLHMCKEAAPTLPLHSICMQFISADFFEGVIELSAVCASKSDPEEVGVHFYNNGEPADDREGYTCFATRMAYYKEVQLM
SQ  LDHIYQRVCNKTHVQDKSINPLKGTAKASDAKNGATQTIPKIVAHTLKVKDPLIHITLYEWLLAHDMLKELLDVVEPSLG
SQ  EFLRRSVSQNVDNVVLIDLLWKYYEKNSHHSQAAHILDNLAMTRSENINLEQRIEYLVRAVMCMRNGNVGSSLSNGIFLK
SQ  ELEDKLDIARVQKSVLAAMTELASDKLEAATAVKELNYALYDITQLYQHFAEPFDLWECQLSILNCSHHNDPLLIESVWG
SQ  QIINSVVDKPGTTSERCNRLFTKIEILVREYGESGVCFPFAFLIRELEVKACQLRFPEGIVPEKLVSMNLDIELLLEYYS
SQ  RMISMNERVWANEGNEWHLIQSVIRVVSLLADNAQSIWYRSKRRIVGKAQDIVAGCLNICYQKPDTNRLQHSLKELQSQL
SQ  QRLLI
//