ID  Q9VEX5;
PN  Protein asunder;
GN  Asun;
OS  7227;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000269|PubMed:19357193, ECO:0000269|PubMed:23097424}. Cytoplasm {ECO:0000269|PubMed:19357193, ECO:0000269|PubMed:23097424, ECO:0000269|PubMed:9799434}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19357193}. Note=Colocalizes with dynein-dynactin on the nuclear surface at the meiotic G2/prophase transition in primary spermatocytes (PubMed:19357193). Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M (PubMed:23904267). {ECO:0000269|PubMed:19357193, ECO:0000269|PubMed:23904267}.
DR  UNIPROT: Q9VEX5;
DR  UNIPROT: Q27924;
DR  UNIPROT: Q7JP08;
DR  Pfam: PF10221;
DE  Function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing (PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5 (PubMed:23097424). Plays a role as a regulator of spermatogenesis (PubMed:19357193). Crucial regulator of the mitotic cell cycle and development (PubMed:15737938, PubMed:19357193). Required for the correct dynein-dynactin perinuclear localization important for nucleus- centrosome coupling that occur upon meiotic progression of primary spermatocytes (PubMed:19357193,PubMed:23904267). Plays a role in sperm motility and fertility (PubMed:19357193). May have a role in the PNG/PLU/GNU pathway (PubMed:15737938). {ECO:0000269|PubMed:15737938, ECO:0000269|PubMed:19357193, ECO:0000269|PubMed:23097424, ECO:0000269|PubMed:23904267}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9VYQ0; IntAct: EBI-224684; Score: 0.00
GO  GO:0005737;
GO  GO:0032039;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0051301;
GO  GO:0051642;
GO  GO:0046843;
GO  GO:0030317;
GO  GO:0051321;
GO  GO:0051663;
GO  GO:0060814;
GO  GO:0080154;
GO  GO:0007346;
GO  GO:0034472;
GO  GO:0007283;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MFERNQKTIFVLDHTRYFSIASEEYISMDFLKGKPSADGGATGAAGNATGSGGSQFSKSLWTCACESSIEYCRVVWDLFP
SQ  GKKHVRFIVSDTAAHIVNTWRPSTQNMAHVMNAMLIVGVPSRNVPTSSDYSVIHGLRAAIEALAEPTDEQLAAMADFGTD
SQ  ELPRIPNKGRVICITSARDNTSMKSLEDIFNTVLVQQNTLAAPPSKKGLVIDHCHLVILNIVPLGVESLVTNRSLLKISP
SQ  LLDVEIHTVSAPDISYKLTHLILNHYDLASTTVTNIPMKEEQNANSSANYDVEILHSRRAHSITCGPDFSLPTSIKQGAT
SQ  YETVTLKWCTPRGCGSADLQPCLGQFLVTPVDVTSRPSSCLINFLLNGRSVLLEMPRKTGSKATSHMLSARGGEIFVHSL
SQ  CITRSCMDEAPSITDGPGGRVSDYRTAELGQLIKMSRVVPLKVKDPSAPPLTRRLPRYFPLTTSSSILFHLQRHISWLPH
SQ  FLHLLVKEDMDKQDEVRCQQHIHELYKSASRGDVLPFTHTNGARLKLSKAKDQYRLLYRELEQLIQLNATTMHHKNLLES
SQ  LQSLRAAYGDAPLKSEPGASLLRTYTESPLSPERLEPISSVGASGSSSSNSLLKASKRRMSSCGQRSLLDIISSAERSQS
SQ  NKRLDFSGRLCTPLGQVAKLYPDFGTKDKDTVTTGASITPNVKEESVRS
//