ID  Q9VIW3;
PN  Ran GTPase-activating protein;
GN  RanGAP;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:17032737}. Nucleus membrane {ECO:0000269|PubMed:17032737, ECO:0000269|PubMed:31626769}; Peripheral membrane protein {ECO:0000269|PubMed:17032737}; Cytoplasmic side {ECO:0000269|PubMed:17032737}. Note=Association to cytoplasmic side of the nuclear pore complex is promoted by Nup214 (PubMed:17032737). Co-localizes with Nup358/RanBP2 to annulate lamellae (PubMed:31626769). {ECO:0000269|PubMed:17032737, ECO:0000269|PubMed:31626769}.
DR  UNIPROT: Q9VIW3;
DR  UNIPROT: Q9XZI5;
DR  Pfam: PF13516;
DE  Function: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion (PubMed:10073941). Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction (PubMed:10073941). During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769). {ECO:0000250|UniProtKB:Q684P5, ECO:0000269|PubMed:10073941, ECO:0000269|PubMed:31626769}.
DE  Reference Proteome: Yes;
DE  Interaction: O77237; IntAct: EBI-277125; Score: 0.00
DE  Interaction: Q9VL21; IntAct: EBI-278977; Score: 0.00
DE  Interaction: P51521; IntAct: EBI-281659; Score: 0.00
DE  Interaction: Q9V428; IntAct: EBI-285284; Score: 0.00
DE  Interaction: Q9UKK6; IntAct: EBI-302158; Score: 0.35
DE  Interaction: Q24570; IntAct: EBI-508117; Score: 0.00
DE  Interaction: P92177; IntAct: EBI-8283416; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005096;
GO  GO:0003723;
GO  GO:0031267;
GO  GO:0090630;
GO  GO:0045132;
GO  GO:0006913;
GO  GO:0043547;
GO  GO:0006611;
GO  GO:0046822;
GO  GO:0007165;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:17032737};
SQ  MSTFNFASMAAQLGQEQGISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALW
SQ  KNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSR
SQ  ALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAFQTLKTFEEIVLEQNSIYIEGVEALAESFKHNPHLRVLNMN
SQ  DNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEINSDGGLVLVNAMGNKPKLR
SQ  ILNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEEVHEHANDTTEEADEDSEGDED
SQ  DEEDEGDEEYSNVAEETAYVTTNAYTTKLFNDTTNSMASETFAVANKTISQKCTPEKFCLSQKPCSQEDFDSLDMDNKLE
SQ  ALQSIVNQFTGDNHLLLLVFTTLKCAHLSQSSKAALDLAVSLYQATFDYAIKTKQETRVLNYVLMQLRLLPCKEVFHSDY
SQ  DVKNCRFALREALKQPTFANDNIKNSFKTFLEGAES
//