ID  Q9VJL6;
PN  Glia maturation factor;
GN  GMF;
OS  7227;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell projection, lamellipodium {ECO:0000269|PubMed:25308079}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25308079}. Nucleus {ECO:0000269|PubMed:25308079}. Cytoplasm, cell cortex {ECO:0000269|PubMed:25308079}. Note=Colocalizes with F-actin and Arp2/3-nucleated actin arrays. {ECO:0000269|PubMed:25308079}.
DR  UNIPROT: Q9VJL6;
DR  UNIPROT: Q8MSR7;
DR  UNIPROT: Q9NK59;
DR  Pfam: PF00241;
DR  PROSITE: PS51263;
DE  Function: Inhibits Arp2/3-mediated actin nucleation (PubMed:25308079). Together with flr, promotes Arp2/3-nucleated actin filament array disassembly (PubMed:25308079). Promotes debranching (PubMed:25308079). Regulates lamellipodial protrusion dynamics possibly by facilitating lamellipodial retraction (PubMed:25308079). In egg chambers, enhances the retraction dynamics of cellular extensions in border cells and thus together with flr plays an important role in directional migration of border cell clusters (PubMed:25308079). {ECO:0000269|PubMed:25308079}.
DE  Reference Proteome: Yes;
DE  Interaction: Q95RB1; IntAct: EBI-238317; Score: 0.00
DE  Interaction: Q9VJA1; IntAct: EBI-242035; Score: 0.00
GO  GO:0071944;
GO  GO:0030027;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0003779;
GO  GO:0071933;
GO  GO:0071846;
GO  GO:0007298;
GO  GO:0034316;
GO  GO:0030833;
GO  GO:0031344;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSDNQICDISNEVLEELKKFRFSKSKNNAALILKVDREKQTVVLDEFIDDISVDELQDTLPGHQPRYVIYTYKMVHDDQR
SQ  ISYPMCFIFYTPRDSQIELQMMYACTKSALQREVDLTRVYEIRELDELTEEWLKAKLK
//