ID  Q9VTL1;
PN  PCI domain-containing protein 2 homolog;
GN  PCID2;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus {ECO:0000269|PubMed:18086857, ECO:0000269|PubMed:27016737}. Cytoplasm {ECO:0000269|PubMed:18086857, ECO:0000269|PubMed:33602059}. Nucleus membrane {ECO:0000269|PubMed:33602059}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:33602059}. Note=Shuttles in and out of the nucleus by a emb/Crm1-dependent mechanism (PubMed:18086857). The ubiquitinated forms are localized to the cytoplasm, the nonubiquitinated forms are localized to the nucleus, and both forms are associated with the nuclear membrane (PubMed:33602059). Associated with cytoplasmic microtubules (PubMed:33602059). Associates with mRNA in the nucleus and cytoplasm (PubMed:33602059). {ECO:0000269|PubMed:18086857, ECO:0000269|PubMed:33602059}.
DR  UNIPROT: Q9VTL1;
DR  Pfam: PF01399;
DR  PROSITE: PS50250;
DE  Function: Required for the export of nuclear mRNAs and involved in mRNA trafficking in the cytoplasm (PubMed:27016737, PubMed:28554770, PubMed:33602059). Component of the nuclear pore complex (NPC)- associated TREX-2/AMEX complex (anchoring and mRNA export complex) which functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), thereby enabling the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:27016737, PubMed:28554770, PubMed:33602059). Within the complex, specifically promotes the association of factors involved in regulating nuclear mRNA export, such as Moe, sbr/NXF1 and the ORC complex, to the mRNPs particles (PubMed:27016737, PubMed:28554770, PubMed:33602059). In the cytoplasm, functions independently of its role in the TREX-2/AMEX complex, to promote cytoplasmic mRNA trafficking together with nudC (PubMed:33602059). Associates with translationally active polysomes (PubMed:18086857). {ECO:0000269|PubMed:18086857, ECO:0000269|PubMed:27016737, ECO:0000269|PubMed:28554770, ECO:0000269|PubMed:33602059}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9VM46; IntAct: EBI-15146793; Score: 0.62
DE  Interaction: O18388; IntAct: EBI-258749; Score: 0.00
GO  GO:0005737;
GO  GO:0005856;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0005844;
GO  GO:0070390;
GO  GO:0003690;
GO  GO:0019904;
GO  GO:0003723;
GO  GO:0006406;
GO  GO:0016973;
GO  GO:0000973;
GO  GO:0015031;
GO  GO:0006417;
GO  GO:0006368;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MFGTVNNYLSGVLHAAQDLDGESLATYLSLRDVHVQNHNLYIAQPEKLVDRFLKPPLDEVVSAHLKVLYHLAQEPPGYME
SQ  AYTQQSAACGAVVRLLQQLKDENWCLPLMYRVCLDLRYLAQACEKHCQGFTPGHVLEKAADCIMACFRVCAADGRASEED
SQ  TKRLGMMNLVNQLFKIYFRINKLHLCKPLIRAIDNCIFKDSFPLPEQITYKYFVGRRAMFDSNYQAAVQYLSYAFSNCPD
SQ  RFASNKRLILIYLVPVKMLLGYLPSKSLLQRYDLLLFLDLAMAMKAGNVNRFDEIVRDQELVLIRSGIYLLVEKLKFLVY
SQ  RNLFKKVFVIRKSHQLDMGDFLSALHFVGLTDVSLDETHCIVANLIYDGKIKGYISHAHNKLVVSKQNPFPSVSL
//