ID  Q9VX31;
PN  Integrator complex subunit 2;
GN  IntS2;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000250|UniProtKB:Q9H0H0}; Single-pass membrane protein {ECO:0000255}.
DR  UNIPROT: Q9VX31;
DR  Pfam: PF14750;
DE  Function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). {ECO:0000250|UniProtKB:Q9H0H0, ECO:0000269|PubMed:21078872, ECO:0000269|PubMed:23097424}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0016021;
GO  GO:0032039;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0010628;
GO  GO:0045666;
GO  GO:0034472;
GO  GO:0016180;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MPVRMYDVSPRVFCAMQNLDITLLASYPEAEIRPVLPSLVRMSLLSPLDNTESSMESRKEILAVLIGIEVVNSIVSYLQV
SQ  NYHELENELKKELQARQKSAFFEGQQHEYGLQSGIALGFERADVARKVRVVLSEIFNLQQQVSEQKPAAHSEMLDDGIYL
SQ  EEVVDILCIALAELPSLLNILELTDALVHVPNGHRIICALVANFPDCYRDVVSHVIANCDEDGSDGKHRLMLLMGLSEMN
SQ  PSQALANRSMCVDMLKVPSFMLKLTLKHPEDLIAFLTGLLLGNDQNLRSWFAAYIRSSQKRKGDALNLVRVELLQKVIQT
SQ  TTNAAELRDFNLQGAVLLRLYCALRGIGGLKFNDDEINALSQLVTSCPQATPSGVRFVTLALCMLIACPSLVSTIPLENK
SQ  AVEWLQWLIREDAFFCKRPGTSTSLGEMLLLLAIHFHSNQISAISEMVCSTLAMKIPIRPNSTNRIKQLFTQDLFTEQVV
SQ  ALHAVRVPVTPNLNGTILCYLPVHCIQQLLKSRTFLKHKVPIKSWIFKQICSSVRPVHPVMPALVEVFVNTLIIPNPTGK
SQ  VNIDHMHRPFTEAEILHVFRTSKLTFFAEELPPMAESQELNQIEVTCPLTAQLLMIYYLMLYEDTRLMNLSALGGRKQKE
SQ  YSNNFLGGLPLKYLLQKAHHYHNDYLSLFHPLLRLIISNYPHLSMVDDWLEEHNLAQGNSTVVVSKHELKPETLDRALAA
SQ  IQTKPHLAIRVFKQLLQMPPETQAQYGQQLVKHLPMVFAKSVPRYVKDLYNDIWLRLNAVLPTTLWIMSLRAITNGSDTM
SQ  DRRTFANESLLEPMEVLSCPRFVFCSPYLLMILLRILKGSLAASKTYLNVHMQMQQKQVLDKNGMMQTDAIWEDLRTTLI
SQ  ASQESAAVHILLEVLDYIASKATDRVSHLELREIQGIIGTYVHQAFISEPSLAKLVHFQTYPKSVIPMMVASVPSMHICI
SQ  DFVHEFLNVTEMEKQIFTIDLTSHLVLNYSIPKSLGVSKFCLNVIQTTLSMLTASTKCRFLRNVMPAMVRFVETFPILAD
SQ  DCVNILMTTGRILHSQSSLGMTTMEMPLTDSDKLCTYRDAQLHIIMIEDAFKALVTAVMKKSDLY
//