ID  Q9VXE6;
PN  Nuclear pore complex protein Nup153;
GN  Nup153;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus {ECO:0000269|PubMed:17682050}. Nucleus membrane {ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17682050, ECO:0000269|PubMed:18562695}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:17682050, ECO:0000269|PubMed:7641726}. Chromosome {ECO:0000269|PubMed:20174442}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18562695}. Note=Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket (PubMed:17682050). Localized at the spindle in mitotic syncytial embryos (PubMed:18562695). Associates with chromatin (PubMed:20174442). {ECO:0000269|PubMed:18562695, ECO:0000269|PubMed:20174442, ECO:0000303|PubMed:17682050}.
DR  UNIPROT: Q9VXE6;
DR  UNIPROT: Q1LZ48;
DR  Pfam: PF00641;
DR  PROSITE: PS01358;
DR  PROSITE: PS50199;
DE  Function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:17682050). Functions as a scaffolding element in the nuclear phase of the NPC (PubMed:17682050). Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner (PubMed:17682050). Required for nuclear import of Mad (PubMed:20547758). Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment (PubMed:20174442). Binds chromatin to nucleoporin- associated regions (NARs) that define transcriptionally active regions of the genome (PubMed:20174442). Associates with extended chromosomal regions that alternate between domains of high density binding with those of low occupancy (PubMed:20174442). Preferentially binds to NARs of the male X chromosome (PubMed:20174442). In males, together with Mtor, required for the localization of the male-specific lethal (MSL) histone acetyltransferase complex to the X chromosome and therefore for the transcription of dosage compensation genes (PubMed:16543150). May play a role in double strand break DNA repair (PubMed:26502056). {ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17682050, ECO:0000269|PubMed:20174442, ECO:0000269|PubMed:20547758, ECO:0000269|PubMed:26502056}.
DE  Reference Proteome: Yes;
DE  Interaction: Q24568; IntAct: EBI-9919289; Score: 0.35
DE  Interaction: P40798; IntAct: EBI-270193; Score: 0.00
DE  Interaction: Q9VPG5; IntAct: EBI-273901; Score: 0.00
DE  Interaction: Q9VVQ1; IntAct: EBI-273906; Score: 0.00
DE  Interaction: P92177; IntAct: EBI-8283416; Score: 0.35
DE  Interaction: Q9VH81; IntAct: EBI-9922589; Score: 0.35
DE  Interaction: P07207; IntAct: EBI-9924105; Score: 0.46
DE  Interaction: P18431; IntAct: EBI-9925534; Score: 0.35
DE  Interaction: Q9VJ30; IntAct: EBI-9932245; Score: 0.35
DE  Interaction: Q9W258; IntAct: EBI-9932835; Score: 0.35
DE  Interaction: M9NFI9; IntAct: EBI-9933573; Score: 0.46
DE  Interaction: Q9GQR5; IntAct: EBI-9935575; Score: 0.35
DE  Interaction: Q9VXY7; IntAct: EBI-9936142; Score: 0.35
DE  Interaction: Q9VDW6; IntAct: EBI-9940412; Score: 0.35
GO  GO:0005737;
GO  GO:0000791;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0034399;
GO  GO:0005643;
GO  GO:0044613;
GO  GO:0005634;
GO  GO:0005819;
GO  GO:0031490;
GO  GO:0046872;
GO  GO:0008139;
GO  GO:0017056;
GO  GO:0006974;
GO  GO:0006325;
GO  GO:0006338;
GO  GO:0007549;
GO  GO:0051028;
GO  GO:0006607;
GO  GO:0006999;
GO  GO:0045944;
GO  GO:0006606;
GO  GO:0006355;
GO  GO:0006405;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEDAQEQRESSQAELAKKHPLTPLKELPEESEEEEEEEDESSAGALRESDSNNSIMGKMKMRVSSILPASLSGWFSPSSK
SQ  DGNDALSSPANLRQSQPRQSNGRLTTKRKRGRRRIMLAEVDADAADDLDDGSDAKGLNYEEVALADNIAEHDLAAEDEQT
SQ  RRSEYNVFLLRKRAGAVAAAGGDEDEAEEDELEEDDEDGDEEDDDEEQENLQQSAAVQTKRRRLELETPVNLPNMRRLPL
SQ  LSSTPAAPLAAATSSSSSQMYKGVSHIAPHRRNHLNLYGSQRQREPAYNFFTGNEAAEGSTGDLPHSIRRSLNIPFGGSS
SQ  TATSYNNSLSSLPNHKRPSLIGKQTHRRDLTMDETGTGPAMSSEEHLNHLLRISRTNNNTSNNNNNNNNNNNVIETKTRR
SQ  SELSAAAGGCGDSQSESDMNEYHDNGEGHDGLRPSHYNSNSNLEFYGNLQSSKSIFNRSNTAAQQSHRNSTWSLNSLTQR
SQ  RRFNASIYGSTSALSDSRLLSGSASNSGSASASSSPFYQGRTTFGGNSGNNRLFSRSNLSSSAASSMLGLNSAGSSPAHQ
SQ  LHASMTGGIGYGMKAVDMRPSDSGSLAETSVGQGGSKKPGTGLSNTTMRILNLLESYSTPLIDAKRMGSSIKEHQSSRQQ
SQ  RQGTPATPYLRSTSASRNVSVPNHINELAELRSNKLLVPTMQQLLERRRLHRVTQNSRDVVHSQNVRAGGENNQEKPKPT
SQ  APYVAPIDQSANHTQHTNKMRSRLSHQTRNKETRTAEEEAPPPLDLPQISFPDMASAPKFDLIIKPTVPVVSKPSTTDPI
SQ  QSSKSSNTNLSTTNSKQMPNFLANPQPAAPIVNFAANGNVSAISKPSKRTFTFSEPTPLSNFQENCIPKPKINRKYTFSA
SQ  PAPLDDLRITNKQSQPTINGTPSSKEWECDTCMVRNKPEINKCVACETAKPVASAAPVQAPLPPSTAAIDTQSFVGFGDR
SQ  FKKSTTAWECDACMLSNKAEASKCIACETPRKTVAPKVNNFSPLITNAKSNEWECSVCLVRNKVEVSKCVACESAKPGAT
SQ  MALPATSNIAVATPSIITDGFGDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIANSSYPSINNNLPAGSGFD
SQ  ISFTRKANMWECQTCLVMNKSSDEECIACQTPNSQARNSNSESALISSISSSSASFSGSLSRPSSRSSSGSTSTCGSVCS
SQ  GSIVSISSTTESAKALSAKKVPPKPDAGFQQLVAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEAFNPAATTANSAAS
SQ  SVPKFRFGFSHVKEVVKPSVETTTTPAPTSAQFSFGFGQSNQGKDVADSKKTEAPKTFMFGVSKVEEPKTVSFGTGIKET
SQ  TATSSTEATAPTPAAAAPAPVQFVFKAPTTATTASSLTTTISTTSNAPALGGFSFGAPSSSSTVSSSTTSTSANPAAVKP
SQ  MFSWSGAGSAVSSTSSSQQPVAKAPTLGFGVSSSTVTTTTTSTKVFAFTPASGLDPAAATSAPAAGAGFSFGSQSKPATT
SQ  QNTGTFFFGQPTAVAPATPTNPSVSSIFGAPATSTTASTSVSATTSTSTANAIASSFAPTSTPQLFGNWGEKKTDLTTFG
SQ  ASSGSGTTTTPSFGWSSNGDAAKSNSAAVGSAAVPSSSASTMATPIFGSSSMFGPSSSSNNTTSTSTTSLPFGSAATTAA
SQ  TTPAGGNAALTGLFGNVGNSLAGVGAPVATTPAATAAAPLTNIFGNPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAP
SQ  ALPGAFNFGGATAATPAASSAPFVFGSSTNEPLAKPSFNFTGSAASSTAPAPAFNFTANTAATNNPSGGDSTPNANALFQ
SQ  FSATSTAPANIFAFNPPAAGNSAQSSQTARRKIRAPVRRLPPR
//