ID  Q9WV78;
PN  Plasmalemma vesicle-associated protein;
GN  Plvap;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000269|PubMed:10366592, ECO:0000269|PubMed:10557298}; Single-pass type II membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000269|PubMed:10366592, ECO:0000269|PubMed:10557298}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15640522}. Note=Membrane-associated protein of caveolae (PubMed:10366592). Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels (PubMed:10557298). Also colocalized with CAV1 in perinuclear region (PubMed:15640522). {ECO:0000269|PubMed:10366592, ECO:0000269|PubMed:10557298, ECO:0000269|PubMed:15640522}.
DR  UNIPROT: Q9WV78;
DR  Pfam: PF06637;
DE  Function: Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. {ECO:0000250|UniProtKB:Q91VC4}.
DE  Reference Proteome: Yes;
DE  Interaction: P15127; IntAct: EBI-10768744; Score: 0.35
GO  GO:0005901;
GO  GO:0009986;
GO  GO:0016021;
GO  GO:0048471;
GO  GO:0042802;
GO  GO:0032502;
GO  GO:0000165;
GO  GO:0002693;
GO  GO:0043114;
GO  GO:0033209;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGLSMDRSPYSRTGDRDRGCWYYLRYFFLFVSLIQFLIILGLVLFMIYGNVHATTESSLRATEIRADNLYSQVVGLSAAQ
SQ  ANLSKQLNISTLVKDTVMQQLLTTRREVERINASFRQCQGDLITYINYNRFIAAIILSEKQCQEQLKEGNKTCEALLFKL
SQ  GEKVKTLEMEVVKEKAVCSKDKDSLLAGKRQAEMQQEACGKAREQQKQDQQVTEEQLRKVQSLCLPLDQEKFQADVLNVW
SQ  RDSLVYRSLDNIGYHYSLMPEFSSLRRTCESLPGIMTTKVEELARGLRAGIERVTRENGELRRQKLELERAIQGEREART
SQ  RAGTEAQARETQLRTECARQTQLALEEKAALRTQRDDLERQLEARKRELEQLRTEVDVRISALDTCVKAKSLPAIQPRLP
SQ  GPPPNPPPIDPASLEEFKKRILESQRPPLVNPAVPPSG
//