ID  Q9WVC5;
PN  Short transient receptor potential channel 7;
GN  Trpc7;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}.
DR  UNIPROT: Q9WVC5;
DR  Pfam: PF12796;
DR  Pfam: PF00520;
DR  Pfam: PF08344;
DE  Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.
DE  Reference Proteome: Yes;
DE  Interaction: Q13563; IntAct: EBI-27054829; Score: 0.40
GO  GO:0034703;
GO  GO:0005801;
GO  GO:0016021;
GO  GO:0005887;
GO  GO:0005635;
GO  GO:0048471;
GO  GO:0070679;
GO  GO:0015279;
GO  GO:0070588;
GO  GO:0006828;
GO  GO:0051480;
GO  GO:0007338;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MLGSNTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQN
SQ  ALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTR
SQ  FSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVL
SQ  TALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNLQVWSDHHRPSLSRIKLAIKYEVK
SQ  KFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGQTLRSPFMKFVAHAVSFTIFLG
SQ  LLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLS
SQ  IFVASFTARFMAFLKASEAQLYVDQYVQDVTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILP
SQ  ANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKY
SQ  DHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYY
SQ  LIMRIKMCLIELCQSKAKRCENDLEMGMLNSKFRKTRYQAGMRNSENLTANSTFSKPTRYQKIMKRLIKRYVLKAQVDRE
SQ  NDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNQGKDI
//