ID  Q9XZ06;
PN  Nuclear pore complex protein Nup93-1;
GN  Nup93;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus membrane {ECO:0000250|UniProtKB:Q8N1F7}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:31784359}. Nucleus, nucleoplasm {ECO:0000269|PubMed:31784359}. Note=When not in the nuclear pore complex, can localize to the nuclear lumen proximal to the inner nuclear membrane. {ECO:0000269|PubMed:31784359}.
DR  UNIPROT: Q9XZ06;
DR  Pfam: PF04097;
DE  Function: Required for nuclear pore complex assembly, maintenance and function (PubMed:20547758, PubMed:22718353). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758). Mediates the association between the nuclear pore complex and a subclass of silenced regions bound by Polycomb group (PcG) proteins, enables long-range interactions between Polycomb loci and contributes to repression of polycomb targets (PubMed:31784359). Together with Nup62 and Nup154, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:26341556). {ECO:0000269|PubMed:20547758, ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:26341556, ECO:0000269|PubMed:31784359}.
DE  Reference Proteome: Yes;
DE  Interaction: Q24568; IntAct: EBI-9944837; Score: 0.35
DE  Interaction: Q9VWS2; IntAct: EBI-26744845; Score: 0.49
DE  Interaction: Q9VYS8; IntAct: EBI-202060; Score: 0.00
DE  Interaction: P54360; IntAct: EBI-207600; Score: 0.00
DE  Interaction: Q9W215; IntAct: EBI-209296; Score: 0.00
DE  Interaction: Q9VH87; IntAct: EBI-209300; Score: 0.00
DE  Interaction: P84029; IntAct: EBI-209304; Score: 0.00
DE  Interaction: A1Z6Z9; IntAct: EBI-209308; Score: 0.00
DE  Interaction: Q9VHK1; IntAct: EBI-209312; Score: 0.00
DE  Interaction: Q9VQE0; IntAct: EBI-209316; Score: 0.00
DE  Interaction: Q9VRS2; IntAct: EBI-209320; Score: 0.00
DE  Interaction: P35381; IntAct: EBI-209324; Score: 0.00
DE  Interaction: Q9Y119; IntAct: EBI-209328; Score: 0.00
DE  Interaction: Q9VQ61; IntAct: EBI-209332; Score: 0.00
DE  Interaction: P07909; IntAct: EBI-209365; Score: 0.00
DE  Interaction: P19538; IntAct: EBI-502459; Score: 0.37
DE  Interaction: P92177; IntAct: EBI-8283416; Score: 0.35
DE  Interaction: Q9VH81; IntAct: EBI-9922589; Score: 0.46
DE  Interaction: P18431; IntAct: EBI-9925534; Score: 0.35
DE  Interaction: P53034; IntAct: EBI-15160117; Score: 0.49
GO  GO:0031965;
GO  GO:0034399;
GO  GO:0005643;
GO  GO:0044615;
GO  GO:0005654;
GO  GO:0003682;
GO  GO:0031490;
GO  GO:0017056;
GO  GO:0097240;
GO  GO:0045814;
GO  GO:0006999;
GO  GO:0030717;
GO  GO:0016973;
GO  GO:0006606;
GO  GO:0036228;
GO  GO:0097298;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDLMELLKQAQRLTNETNTDTEVPGVERTMSQVLQATKEFHSRVTQMGTNDLQAHILLGSKGVDLPKLTQKLESLSARQT
SQ  FEPIDPVTETNVQAYLKNERENAILSVIDETNRSIFKSVERQKWRCIYSEWGEEKEALLNALVGPNQQDFPDVQFQIVPT
SQ  AMADEPTPYSQLNGHEQMYAEQIAIHNQSIILGRRPNLLSTLAHVVQDSFNDESVAEMWNVLQFMTALPPVSSTIDPIKN
SQ  RQTSPQFVEQARTYLERRYRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGLHDVNNGQPLWPHVYYSL
SQ  RSGDMDAAALYLKESGTCPDLLTLLTLRKNGDRDNLMVKLEGQLKLEYNSRLRACTDPYKKAVYVVLLACDPHFTHVELM
SQ  RSIDDFLWMQLSILRRSDQSDSNTEQLTFSGLQSLILEKYGENYFNAREKAALYFQVLTLTGQFEAAIEFLARTEKNRTH
SQ  AIHMAIALNEISMLGTPRSVEQSLLSSDPDDPKPMKRLNLVRLIVMYTKCFERTDTTQALHYYYLLRNFKSENGRGNVML
SQ  TCVCDLLVEKCDDEMLELIFGTEDKKNGLRYGGIYAEFQIHECDKYSLAEMVGDELSKRGDYELAIELYFIGGQLDKALR
SQ  LVNSLLAQVVHQPTQNGSVRNRLGDIINRLDAALVVRKSDVEVQVVVTYTVLTKVMKFFDHYHEGALRSALEILTNNHLI
SQ  PASSLEVDECVTNIKRMGPEVIKVLPDILLASMDIVYQEYVKLMDSNETASGFFDESKCVNKEPAVKHLRDRAKAFTNMA
SQ  ASVPYRMPSTTNQRLVQLEILMH
//