ID  Q9Y0E4;
PN  Klarsicht protein;
GN  klar;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10556085, ECO:0000269|PubMed:15579692, ECO:0000269|PubMed:18820457, ECO:0000269|PubMed:22927463}. Nucleus membrane {ECO:0000269|PubMed:14617811, ECO:0000269|PubMed:15579692, ECO:0000269|PubMed:18820457}. Nucleus envelope {ECO:0000269|PubMed:14617811}. Note=Associated with microtubules, both apical to the nucleus and also at the basal-most area of the eye disk (PubMed:15579692, PubMed:18820457, PubMed:14617811). Koi is required for perinuclear localization of Klar (PubMed:18820457). Nuclear envelope localization requires nuclear lam (PubMed:14617811). {ECO:0000269|PubMed:14617811, ECO:0000269|PubMed:15579692, ECO:0000269|PubMed:18820457}.
DR  UNIPROT: Q9Y0E4;
DR  Pfam: PF10541;
DR  PROSITE: PS51049;
DE  Function: Component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (By similarity). Plays a role in the nuclear positioning and links the nucleus to the microtubule organizing center (MTOC) (PubMed:10556085, PubMed:22927463, PubMed:15579692). Collaborates with Klar to promote even spacing of the myonuclei at the periphery of striated muscle fibers by mediating a tight association between a nuclear ring structure of Msp300 and the plus ends of a unique astral microtubule (MT) network (PubMed:22927463). {ECO:0000250|UniProtKB:Q8WXH0, ECO:0000269|PubMed:10556085, ECO:0000269|PubMed:15579692, ECO:0000269|PubMed:22927463}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8MQJ7; IntAct: EBI-467675; Score: 0.00
DE  Interaction: P50445; IntAct: EBI-467678; Score: 0.00
GO  GO:0005737;
GO  GO:0016021;
GO  GO:0005874;
GO  GO:0005635;
GO  GO:0005640;
GO  GO:0048471;
GO  GO:0019894;
GO  GO:0001745;
GO  GO:0042051;
GO  GO:0060361;
GO  GO:0007523;
GO  GO:0031887;
GO  GO:0006869;
GO  GO:0040011;
GO  GO:0035149;
GO  GO:0061024;
GO  GO:0034453;
GO  GO:0045855;
GO  GO:0007097;
GO  GO:0051647;
GO  GO:0006997;
GO  GO:0032386;
GO  GO:0035239;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255|PROSITE-ProRule:PRU00385};
SQ  MEMQQENETGREGVIPNSEKEVALISNQETEKAAMISGGKEGSVRDLESPNETATTQKIEHTTKPLKLDGIFAMPATPPN
SQ  KAGLATKSASSSRSSSLKKQRRGSRGSANLNVAGMGDGAPKRSAPGGGQLNYGTNSVGNDLMKQSQSMTSLKASNEEQQE
SQ  SRDVIQAKLHLERPYNSLKKNSHSNKMHRYSWGSGNSQCSSTSLHSSATLGLGSSGKDDLWAAIQTNYNYIMDTNLLDTC
SQ  KEARCEIEGAATVLEKSSECSFKMLDETQRPEGLCEDPKELRRSWREMENKLESSPTITELTLFGNAELQRHLAVHSVLY
SQ  HEIASHARVVSSCIRAAEKEQQLQQQQQLSSQQPASLTSNCSSESTSESATKSSSLSSGFASDPVTTPIGTAAAAPPSSS
SQ  THPSKKGEGNLERLRDRYHLLYLKAFELQLCLDNLLRKRSSAANGLDDDEDEEEDTEDDSFGYEGEATEDDLNEVNSDLD
SQ  LENSESKSATPAELILQRCQIAATQIVCGLDETQSQSRSQQVPSQAKSPSADQPRDCLAPQKPGDEADEELEEEDEDPDI
SQ  GTDVVDFLIAKRSWRQVNHPNPSGTATLTDFEADSESSDFEQVQQLSRRGLPPTVGSTRRVLNLIEMPQSSNTNISSSNS
SQ  LLQQRNHNIGNKMLPNKAHGKNIAVAVITPNSHGNTSHGHGLGHGLGHELNKSPLGLRKTRHHHNDTSKFNRSNRKSKNC
SQ  AIFYFKHLDTDNEQGNAAGSDLQSEDDPSLIHRRRAGGDILKSADASTDDDDEGCLYTATAAATLEVATAATAAPTAAAA
SQ  TSSVDGLQSTAVSSTTATGGPLPPSDDSDKENKVALVSASTITAARTATATSIATLHSSNYDSSSACSSSNSNSNSNSNS
SQ  NGRLTETSATSRVTQLQMQIHSQSQSQSQMELQINGNAIDGRHIISNNNCYSSMQHQPQNNNEGEAAEDLAKIKMGDDEA
SQ  AADMANGNATKSQQMSNGVYSRADSCNFTVWAAETVASCHLPPRSPAKSAKSTKSQASNATVSGSTLVSPVKGKVSHDSI
SQ  KQLVLKAEHLVRDAQETALKTPTKQKHSIIKISSTVKKREVTMPHPIKQRVEEWLEHQPSTPQLLTRSHTNELLPSCKPD
SQ  DCEASGEASETDSVPQAGAGVNGGAPNGAGSDTSEGFTDSIATCMQTSTNSYGNSTERIGGSAEPIGQPVTPLGFGSSNQ
SQ  SLNVKIVKRSQTRRKSERPWSVSCLSQLTTDAAQLTTARIVENSPSGLASHSISESALDSLSPGPRPRAASSSGTGSNAA
SQ  KKADSKGSLRRRKARKKRISAASAGRKSDSGSELGGDLTQTLMKSCESMSSQQLQEFTNALLSIQKGAVVAPLSPKGEVS
SQ  GVPSLHDGEGGETQLMLPKFRVGSFTTAGLLATDTRLGALAALSNYMNEDEQQAELSTEDHHSSISETAWDNYQEKYNSE
SQ  NYSEGFDSDAARRLLEFGDDYRNFIDSQSDCCSSLSAANNLDSFSPPRMDSLQKHELKSLHINQDTITSSVDHARRQRAL
SQ  ELQYERRRKTLEVRRKSCQDMDESLMASPQSDQQQQQLQVTPSLSASATALMTTPKNQSTSHQISHRAESVGRKLDFGGM
SQ  SHSAQSLLRRTSESDTSTRRRRTVTADERRRSSRNLEKCIKLIPATTSSSSGSDSEDGEQEMRSLLQQSRDRLDDTRALK
SQ  IRCHLLRPEDYNEIINTCRDNIRCLEAVLRGPPGTVLSNHCAGQTKDLLGAWEDLLSWSENASAARKLQQEMSVLKSSLQ
SQ  RLGDKPTPELLDTEPAIQIAVEALKLEQTQLTSYRTNMLRLNASVHSWLTKQERRLQSALEEQEQQQESEQLKQQKLVEE
SQ  EKGADVQKELASTGAVAITVTDSNGNQVEALATGEASTSTPAWDVHSLMSSEQEFHKHLKNEVSDMYSAWDEADARINTQ
SQ  LEMLTNSLIAWRQLESGLSEFQLALGQDRGTLKGLEGALDKGQATPVELAQNVKLVAKLLSEKVHVSQEQLLAVQQHLDP
SQ  NHIYHITKFTASNGSLSDSGISDGGATSDGGLSERERRLGVLRRLAKQLELALAPGSEAMRSIAARMESAEADLKHLQNT
SQ  CRDLIVRTAASHQQKQQIQQNQTQQVSPKANGHIKKQAAKGKAEPQSPGRRGKGARKARQAKKAGEDQQVEEPSLSPEQQ
SQ  KMVLKQLKTLTSGDGGDDPSDDPSLLFNLESSEEDGEGADPAQTSKRGWAWRIARAAVPMQVALFTIFCAACLMQPNCCD
SQ  NLNNLSMSFTPQLRYIRGPPPI
//