ID  Q9Y217;
PN  Myotubularin-related protein 6;
GN  MTMR6;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:19038970}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:19038970}. Endoplasmic reticulum {ECO:0000269|PubMed:19038970}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q8VE11}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19038970}. Note=Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR9 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970). Co-localizes with RAB1B to the endoplasmic reticulum-Golgi intermediate compartment and to the peri- Golgi region (By similarity). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000250|UniProtKB:Q8VE11, ECO:0000269|PubMed:19038970}.
DR  UNIPROT: Q9Y217;
DR  UNIPROT: B2RBB5;
DR  UNIPROT: B3KSB4;
DR  UNIPROT: Q5JRG6;
DR  UNIPROT: Q86TB7;
DR  UNIPROT: Q86YH4;
DR  UNIPROT: Q96P80;
DR  PDB: 2YF0;
DR  Pfam: PF06602;
DR  PROSITE: PS51339;
DR  PROSITE: PS00383;
DR  OMIM: 603561;
DR  DisGeNET: 9107;
DE  Function: Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315, ECO:0000269|PubMed:19038970, ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:24591580, ECO:0000305|PubMed:24591580}.
DE  Reference Proteome: Yes;
DE  Interaction: P00533; IntAct: EBI-32720286; Score: 0.27
DE  Interaction: Q6ZMQ8; IntAct: EBI-20980286; Score: 0.37
DE  Interaction: Q96QG7; IntAct: EBI-8657967; Score: 0.85
DE  Interaction: P41182; IntAct: EBI-765648; Score: 0.35
DE  Interaction: P13631; IntAct: EBI-3912831; Score: 0.37
DE  Interaction: P14373; IntAct: EBI-10325112; Score: 0.56
DE  Interaction: Q13287; IntAct: EBI-10325124; Score: 0.56
DE  Interaction: Q5JR59; IntAct: EBI-10325134; Score: 0.56
DE  Interaction: Q9Y2J4; IntAct: EBI-10325166; Score: 0.56
DE  Interaction: Q86X19; IntAct: EBI-11372615; Score: 0.27
DE  Interaction: Q96LK0; IntAct: EBI-11376319; Score: 0.27
DE  Interaction: Q15468; IntAct: EBI-11383475; Score: 0.27
DE  Interaction: Q5SW79; IntAct: EBI-11385552; Score: 0.27
DE  Interaction: P49286; IntAct: EBI-11577362; Score: 0.00
DE  Interaction: Q9NXW9; IntAct: EBI-14032135; Score: 0.37
DE  Interaction: Q8N5Z5; IntAct: EBI-21592259; Score: 0.35
DE  Interaction: P32320; IntAct: EBI-21622979; Score: 0.35
DE  Interaction: P14091; IntAct: EBI-21699601; Score: 0.35
DE  Interaction: O95229; IntAct: EBI-21701899; Score: 0.35
DE  Interaction: P48544; IntAct: EBI-21754197; Score: 0.35
DE  Interaction: O00506; IntAct: EBI-21762390; Score: 0.35
DE  Interaction: Q9Y216; IntAct: EBI-21836819; Score: 0.35
DE  Interaction: Q93088; IntAct: EBI-21899859; Score: 0.35
DE  Interaction: P49789; IntAct: EBI-21901559; Score: 0.40
DE  Interaction: O43493; IntAct: EBI-16800265; Score: 0.27
DE  Interaction: Q8IWU2; IntAct: EBI-20979922; Score: 0.37
DE  Interaction: Q15303; IntAct: EBI-20980456; Score: 0.37
DE  Interaction: P21860; IntAct: EBI-20981026; Score: 0.37
DE  Interaction: Q01974; IntAct: EBI-20981820; Score: 0.37
DE  Interaction: Q13308; IntAct: EBI-20982464; Score: 0.37
DE  Interaction: Q92878; IntAct: EBI-20927160; Score: 0.40
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P69479; IntAct: EBI-25568051; Score: 0.35
DE  Interaction: P35226; IntAct: EBI-27109494; Score: 0.35
DE  Interaction: P11362; IntAct: EBI-32721578; Score: 0.27
DE  Interaction: P21802; IntAct: EBI-32721907; Score: 0.27
DE  Interaction: P22455; IntAct: EBI-32722168; Score: 0.27
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005793;
GO  GO:0005635;
GO  GO:0048471;
GO  GO:0032587;
GO  GO:0052629;
GO  GO:0106018;
GO  GO:0004438;
GO  GO:0004722;
GO  GO:0004725;
GO  GO:0006897;
GO  GO:0006661;
GO  GO:0046856;
GO  GO:0006470;
TP  Membrane Topology: Peripheral; Source: UniProt - Curator Inference {ECO:0000305};
SQ  MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLALTTSGCPLVIQCKNFRTVHF
SQ  IVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYP
SQ  RELYVPRIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTR
SQ  PKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIF
SQ  LAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQF
SQ  LECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRF
SQ  TVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPE
SQ  SPNLKTSLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC
//