ID  Q9Y224;
PN  RNA transcription, translation and transport factor protein;
GN  RTRAF;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, cytosol {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15147888}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15147888}. Note=May localize at the centrosome during mitosis (PubMed:15147888). Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Nucleus {ECO:0000269|PubMed:26864902}. Cytoplasm {ECO:0000269|PubMed:26864902}. Note=(Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed:21900157, PubMed:26864902). {ECO:0000269|PubMed:21900157, ECO:0000269|PubMed:26864902}.
DR  UNIPROT: Q9Y224;
DR  PDB: 7P3A;
DR  Pfam: PF10036;
DR  OMIM: 610858;
DR  DisGeNET: 51637;
DE  Function: RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264). {ECO:0000269|PubMed:16950395, ECO:0000269|PubMed:24608264, ECO:0000269|PubMed:24870230}. (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157). {ECO:0000269|PubMed:21900157}.
DE  Reference Proteome: Yes;
DE  Interaction: O75190; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: P59595; IntAct: EBI-27129966; Score: 0.35
DE  Interaction: Q92905; IntAct: EBI-21325777; Score: 0.35
DE  Interaction: P63104; IntAct: EBI-7195640; Score: 0.40
DE  Interaction: Q9NRI5; IntAct: EBI-1105474; Score: 0.00
DE  Interaction: Q8N4C6; IntAct: EBI-1164109; Score: 0.56
DE  Interaction: Q9Y224; IntAct: EBI-1164152; Score: 0.73
DE  Interaction: A0A2B6C7W6; IntAct: EBI-2811250; Score: 0.00
DE  Interaction: A0A3Q0PRD7; IntAct: EBI-2817447; Score: 0.00
DE  Interaction: Q81VT8; IntAct: EBI-2817440; Score: 0.00
DE  Interaction: A0A6L8P1C8; IntAct: EBI-2836006; Score: 0.00
DE  Interaction: P60520; IntAct: EBI-3046676; Score: 0.35
DE  Interaction: P31343; IntAct: EBI-5452624; Score: 0.58
DE  Interaction: P24928; IntAct: EBI-6050476; Score: 0.40
DE  Interaction: Q1K9H5; IntAct: EBI-6050645; Score: 0.35
DE  Interaction: B4URF7; IntAct: EBI-6050645; Score: 0.43
DE  Interaction: Q1I2B2; IntAct: EBI-6050645; Score: 0.35
DE  Interaction: P98078; IntAct: EBI-6100356; Score: 0.35
DE  Interaction: O56264; IntAct: EBI-6157161; Score: 0.35
DE  Interaction: P12792; IntAct: EBI-6159029; Score: 0.35
DE  Interaction: D1LN35; IntAct: EBI-6159328; Score: 0.35
DE  Interaction: P02751; IntAct: EBI-6285956; Score: 0.35
DE  Interaction: Q86VP6; IntAct: EBI-21322532; Score: 0.35
DE  Interaction: Q13616; IntAct: EBI-21323857; Score: 0.35
DE  Interaction: Q96GG9; IntAct: EBI-21325177; Score: 0.35
DE  Interaction: Q13617; IntAct: EBI-21327106; Score: 0.35
DE  Interaction: Q13620; IntAct: EBI-21327757; Score: 0.35
DE  Interaction: Q13618; IntAct: EBI-21329068; Score: 0.35
DE  Interaction: Q93034; IntAct: EBI-21331078; Score: 0.35
DE  Interaction: Q8NCA5; IntAct: EBI-10269246; Score: 0.81
DE  Interaction: O60307; IntAct: EBI-10103761; Score: 0.35
DE  Interaction: P05412; IntAct: EBI-11323169; Score: 0.35
DE  Interaction: Q6ZWV7; IntAct: EBI-10997876; Score: 0.35
DE  Interaction: Q96FV9; IntAct: EBI-11034504; Score: 0.35
DE  Interaction: P27635; IntAct: EBI-11035646; Score: 0.35
DE  Interaction: Q8R050; IntAct: EBI-11056816; Score: 0.35
DE  Interaction: Q99PL5; IntAct: EBI-11066888; Score: 0.35
DE  Interaction: O00567; IntAct: EBI-11069711; Score: 0.35
DE  Interaction: P43243; IntAct: EBI-11071398; Score: 0.35
DE  Interaction: Q16643; IntAct: EBI-11080402; Score: 0.35
DE  Interaction: Q00839; IntAct: EBI-11088773; Score: 0.35
DE  Interaction: P25206; IntAct: EBI-11097548; Score: 0.35
DE  Interaction: Q8CCJ3; IntAct: EBI-11104920; Score: 0.35
DE  Interaction: Q67020; IntAct: EBI-11514481; Score: 0.57
DE  Interaction: P03433; IntAct: EBI-11514611; Score: 0.37
DE  Interaction: Q9UIG4; IntAct: EBI-24776957; Score: 0.56
DE  Interaction: Q194T2; IntAct: EBI-12587457; Score: 0.35
DE  Interaction: P46531; IntAct: EBI-13915571; Score: 0.35
DE  Interaction: Q6ZNJ1; IntAct: EBI-16749633; Score: 0.35
DE  Interaction: Q7KZN9; IntAct: EBI-20304305; Score: 0.35
DE  Interaction: P09622; IntAct: EBI-20304669; Score: 0.35
DE  Interaction: O00429; IntAct: EBI-20305770; Score: 0.35
DE  Interaction: P00441; IntAct: EBI-20307497; Score: 0.35
DE  Interaction: Q9Y2H1; IntAct: EBI-20624829; Score: 0.27
DE  Interaction: P51957; IntAct: EBI-20721387; Score: 0.35
DE  Interaction: P10636; IntAct: EBI-20798291; Score: 0.35
DE  Interaction: Q9BVC5; IntAct: EBI-20916280; Score: 0.40
DE  Interaction: Q52LJ0; IntAct: EBI-20924042; Score: 0.56
DE  Interaction: Q92499; IntAct: EBI-20924034; Score: 0.64
DE  Interaction: A2A935; IntAct: EBI-21022882; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: O96013; IntAct: EBI-26962273; Score: 0.35
DE  Interaction: Q9Y586; IntAct: EBI-21261050; Score: 0.35
DE  Interaction: Q9Y3I0; IntAct: EBI-21264222; Score: 0.68
DE  Interaction: P35637; IntAct: EBI-21208916; Score: 0.35
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: A0A024R136; IntAct: EBI-25411916; Score: 0.35
DE  Interaction: A0A0H3L6J6; IntAct: EBI-25401190; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P15884; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: Q9BWW4; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: Q9NQ29; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: Q9H1R3; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: P28288; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: Q92804; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: P51572; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: Q9NVH1; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: Q08378; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: Q17RN3; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: P62979; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: Q9H0W5; IntAct: EBI-26615064; Score: 0.35
DE  Interaction: P0DTC9; IntAct: EBI-26994159; Score: 0.53
DE  Interaction: P35226; IntAct: EBI-27108918; Score: 0.35
DE  Interaction: Q8N488; IntAct: EBI-27111302; Score: 0.35
DE  Interaction: Q99592; IntAct: EBI-27093179; Score: 0.35
DE  Interaction: Q9BVS4; IntAct: EBI-28944998; Score: 0.35
DE  Interaction: P15130; IntAct: EBI-27131516; Score: 0.35
DE  Interaction: Q0ZME3; IntAct: EBI-27131755; Score: 0.35
DE  Interaction: Q6Q1R8; IntAct: EBI-27132003; Score: 0.35
DE  Interaction: K9N4V7; IntAct: EBI-27132270; Score: 0.35
DE  Interaction: P33469; IntAct: EBI-27132272; Score: 0.35
GO  GO:0005813;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0072686;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0072669;
GO  GO:0042802;
GO  GO:0003723;
GO  GO:0000993;
GO  GO:0006469;
GO  GO:0045944;
GO  GO:0050658;
GO  GO:0006388;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MFRRKLTALDYHNPAGFNCKDETEFRNFIVWLEDQKIRHYKIEDRGNLRNIHSSDWPKFFEKYLRDVNCPFKIQDRQEAI
SQ  DWLLGLAVRLEYGDNAEKYKDLVPDNSKTADNATKNAEPLINLDVNNPDFKAGVMALANLLQIQRHDDYLVMLKAIRILV
SQ  QERLTQDAVAKANQTKEGLPVALDKHILGFDTGDAVLNEAAQILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLG
SQ  KVGR
//