ID  Q9Y2K6;
PN  Ubiquitin carboxyl-terminal hydrolase 20;
GN  USP20;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23486064}. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
DR  UNIPROT: Q9Y2K6;
DR  UNIPROT: Q541F1;
DR  UNIPROT: Q8IXQ1;
DR  UNIPROT: Q96LG5;
DR  UNIPROT: Q9UQN8;
DR  UNIPROT: Q9UQP0;
DR  PDB: 6KCZ;
DR  Pfam: PF06337;
DR  Pfam: PF00443;
DR  Pfam: PF02148;
DR  PROSITE: PS51283;
DR  PROSITE: PS00972;
DR  PROSITE: PS00973;
DR  PROSITE: PS50235;
DR  PROSITE: PS50271;
DR  OMIM: 615143;
DR  DisGeNET: 10868;
DE  Function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180}.
DE  Reference Proteome: Yes;
DE  Interaction: P49790; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q96AG4; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q9P0L0; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q9UH99; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P35249; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P35250; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: O00232; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: O15049; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P40938; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: O75521; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q6IQ21; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q96JN8; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P62158; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q99666; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P60228; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P22830; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q5T9A4; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q68DG8; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q15008; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q15149; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q96C24; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P53350; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: O75943; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: O00231; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: O00159; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P51665; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: O75787; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: P15374; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q6IQ23; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: O95292; IntAct: EBI-2512022; Score: 0.68
DE  Interaction: Q99767; IntAct: EBI-2512022; Score: 0.56
DE  Interaction: P11310; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q9UBC5; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q3KQU3; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q8TD30; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q9BY77; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: O95714; IntAct: EBI-2512022; Score: 0.56
DE  Interaction: Q99613; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q9UK80; IntAct: EBI-2512177; Score: 0.40
DE  Interaction: O95931; IntAct: EBI-3951830; Score: 0.64
DE  Interaction: O43597; IntAct: EBI-10326535; Score: 0.56
DE  Interaction: P13196; IntAct: EBI-10326545; Score: 0.56
DE  Interaction: P36406; IntAct: EBI-10326555; Score: 0.56
DE  Interaction: P43364; IntAct: EBI-10326565; Score: 0.56
DE  Interaction: Q53XM7; IntAct: EBI-10326577; Score: 0.56
DE  Interaction: Q7L4P6; IntAct: EBI-10326587; Score: 0.56
DE  Interaction: Q8IYA8; IntAct: EBI-10326597; Score: 0.56
DE  Interaction: Q8N7W2; IntAct: EBI-10326607; Score: 0.56
DE  Interaction: Q969F0; IntAct: EBI-10326619; Score: 0.56
DE  Interaction: Q99750; IntAct: EBI-10326629; Score: 0.56
DE  Interaction: P58304; IntAct: EBI-21789618; Score: 0.35
DE  Interaction: Q96T17; IntAct: EBI-21796065; Score: 0.35
DE  Interaction: Q9UJU6; IntAct: EBI-21796190; Score: 0.35
DE  Interaction: Q96RY5; IntAct: EBI-21885721; Score: 0.35
DE  Interaction: Q9NZ08; IntAct: EBI-20900752; Score: 0.40
DE  Interaction: Q9H492; IntAct: EBI-30830405; Score: 0.44
GO  GO:0005813;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0004843;
GO  GO:0004197;
GO  GO:0001664;
GO  GO:0008270;
GO  GO:0006897;
GO  GO:0016579;
GO  GO:0071108;
GO  GO:0070536;
GO  GO:0008277;
GO  GO:0006511;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHAQAKKHNLTVNLTTFR
SQ  LWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAAL
SQ  QALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM
SQ  DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGRGGGSSQAETELLIPDEAGRA
SQ  ISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHE
SQ  GHAKLSSSPPRASPVRMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP
SQ  GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKGDNMYSC
SQ  ERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAG
SQ  SGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF
SQ  NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVCSICQVEIEALAKRRRIEIDT
SQ  FIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPPGPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLY
SQ  GGGPEIAIRQSVAQPLGPENLHGEQKIEAETRAV
//