ID  Q9Y6D6;
PN  Brefeldin A-inhibited guanine nucleotide-exchange protein 1;
GN  ARFGEF1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus {ECO:0000269|PubMed:12571360}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27373159, ECO:0000269|PubMed:27436755}. Nucleus {ECO:0000269|PubMed:14973189}. Nucleus, nucleolus {ECO:0000269|PubMed:14973189}. Nucleus matrix {ECO:0000269|PubMed:14973189}. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.
DR  UNIPROT: Q9Y6D6;
DR  UNIPROT: Q9NV46;
DR  UNIPROT: Q9UFV2;
DR  UNIPROT: Q9UNL0;
DR  PDB: 3LTL;
DR  PDB: 5EE5;
DR  PDB: 5J5C;
DR  Pfam: PF16213;
DR  Pfam: PF09324;
DR  Pfam: PF01369;
DR  Pfam: PF12783;
DR  PROSITE: PS50190;
DR  OMIM: 604141;
DR  DisGeNET: 10565;
DE  Function: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}.
DE  Reference Proteome: Yes;
DE  Interaction: D4A631; IntAct: EBI-6251296; Score: 0.40
DE  Interaction: P0DTC7; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: P37198; IntAct: EBI-15687558; Score: 0.35
DE  Interaction: Q13459; IntAct: EBI-6251244; Score: 0.56
DE  Interaction: Q5SQN1; IntAct: EBI-11294278; Score: 0.37
DE  Interaction: Q9Y6D5; IntAct: EBI-6249183; Score: 0.79
DE  Interaction: O75365; IntAct: EBI-1074175; Score: 0.00
DE  Interaction: P0DPB3; IntAct: EBI-2679560; Score: 0.00
DE  Interaction: A0A6L7HGG4; IntAct: EBI-2837534; Score: 0.00
DE  Interaction: A0A3N4AWL6; IntAct: EBI-2848506; Score: 0.00
DE  Interaction: P0DOE9; IntAct: EBI-6138583; Score: 0.35
DE  Interaction: P05919; IntAct: EBI-6175288; Score: 0.46
DE  Interaction: Q7Z4S6; IntAct: EBI-6251652; Score: 0.71
DE  Interaction: Q99417; IntAct: EBI-6251879; Score: 0.54
DE  Interaction: Q9UQV4; IntAct: EBI-21563011; Score: 0.35
DE  Interaction: P49146; IntAct: EBI-21569349; Score: 0.35
DE  Interaction: Q8N7X8; IntAct: EBI-21585341; Score: 0.35
DE  Interaction: P01889; IntAct: EBI-21611619; Score: 0.35
DE  Interaction: P24530; IntAct: EBI-21672284; Score: 0.35
DE  Interaction: O95988; IntAct: EBI-21767396; Score: 0.35
DE  Interaction: Q6DKI7; IntAct: EBI-21808409; Score: 0.35
DE  Interaction: Q8TDX6; IntAct: EBI-21888284; Score: 0.35
DE  Interaction: P36873; IntAct: EBI-15627579; Score: 0.40
DE  Interaction: P19338; IntAct: EBI-15687524; Score: 0.50
DE  Interaction: P22087; IntAct: EBI-15687576; Score: 0.35
DE  Interaction: P05455; IntAct: EBI-15687649; Score: 0.35
DE  Interaction: Q14432; IntAct: EBI-15766317; Score: 0.58
DE  Interaction: P10644; IntAct: EBI-15766462; Score: 0.50
DE  Interaction: Q14678; IntAct: EBI-15953570; Score: 0.63
DE  Interaction: O15155; IntAct: EBI-16788067; Score: 0.27
DE  Interaction: Q00839; IntAct: EBI-20927272; Score: 0.40
DE  Interaction: P05787; IntAct: EBI-20930720; Score: 0.40
DE  Interaction: Q9NU19; IntAct: EBI-21228134; Score: 0.35
DE  Interaction: Q9NRI5; IntAct: EBI-21370268; Score: 0.00
DE  Interaction: P0DTC5; IntAct: EBI-25685699; Score: 0.35
DE  Interaction: Q5EP34; IntAct: EBI-25772822; Score: 0.35
GO  GO:0005829;
GO  GO:0005794;
GO  GO:0000139;
GO  GO:0016363;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0048471;
GO  GO:0030532;
GO  GO:0005802;
GO  GO:0005085;
GO  GO:0017022;
GO  GO:0034237;
GO  GO:0010256;
GO  GO:0006887;
GO  GO:0007030;
GO  GO:0030837;
GO  GO:0034260;
GO  GO:0090303;
GO  GO:0006486;
GO  GO:0015031;
GO  GO:0032012;
GO  GO:2000114;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKY
SQ  FLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVT
SQ  SQHIEIHEGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHE
SQ  PESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHD
SQ  CEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGTIEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDT
SQ  QESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINA
SQ  IKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSFDHKWMVIQTLTRICADAQ
SQ  SVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTL
SQ  GQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
SQ  QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRL
SQ  MEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGK
SQ  KISMKETKELTIPTKSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAF
SQ  SVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTIKTLITVAHTDGNYL
SQ  GNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSLTGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQS
SQ  VVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGC
SQ  NPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFS
SQ  VFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQA
SQ  FKEYTSDDMNVAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKL
SQ  PEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIW
SQ  DKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEKPLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVS
SQ  KIKSTAKFPEQKLFAALLIKCVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLF
SQ  KLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCSE
SQ  ALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRFKAHASFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPP
SQ  EQELGINKQ
//