ID  Q9Y6F6;
PN  Inositol 1,4,5-triphosphate receptor associated 1;
GN  IRAG1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Sarcoplasmic reticulum {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
DR  UNIPROT: Q9Y6F6;
DR  UNIPROT: B7Z3T4;
DR  UNIPROT: B7Z6I2;
DR  UNIPROT: B7Z9A3;
DR  UNIPROT: E9PQY6;
DR  UNIPROT: F5H6A1;
DR  UNIPROT: J3KQZ7;
DR  UNIPROT: Q17S00;
DR  UNIPROT: Q9UNY1;
DR  Pfam: PF05781;
DR  OMIM: 604673;
DR  DisGeNET: 10335;
DE  Function: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO- dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. {ECO:0000269|PubMed:14729908}.
DE  Reference Proteome: Yes;
DE  Interaction: P08473; IntAct: EBI-1389788; Score: 0.35
DE  Interaction: Q5NFP9; IntAct: EBI-22298736; Score: 0.37
DE  Interaction: Q5NHT8; IntAct: EBI-22298726; Score: 0.37
DE  Interaction: Q5NHH2; IntAct: EBI-22298746; Score: 0.37
DE  Interaction: Q5NEC5; IntAct: EBI-22298756; Score: 0.37
DE  Interaction: P07339; IntAct: EBI-25840046; Score: 0.56
DE  Interaction: P28799; IntAct: EBI-25860891; Score: 0.56
DE  Interaction: O76024; IntAct: EBI-25898051; Score: 0.56
DE  Interaction: Q7Z699; IntAct: EBI-25931556; Score: 0.56
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0048471;
GO  GO:0031095;
GO  GO:0016529;
GO  GO:0019934;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGMDLTCPFGISPACGAQASWSIFGADAAEVPGTRGHSQQEAAMPHIPEDEEPPGEPQAAQSPAGQGPPAAGVSCSPTPT
SQ  IVLTGDATSPEGETDKNLANRVHSPHKRLSHRHLKVSTASLTSVDPAGHIIDLVNDQLPDISISEEDKKKNLALLEEAKL
SQ  VSERFLTRRGRKSRSSPGDSPSAVSPNLSPSASPTSSRSNSLTVPTPPGLDVCSGPPSPLPGAPPQQKGDEADVSSPHPG
SQ  EPNVPKGLADRKQNDQRKVSQGRLAPRPPPVEKSKEIAIEQKENFDPLQYPETTPKGLAPVTNSSGKMALNSPQPGPVES
SQ  ELGKQLLKTGWEGSPLPRSPTQDAAGVGPPASQGRGPAGEPMGPEAGSKAELPPTVSRPPLLRGLSWDSGPEEPGPRLQK
SQ  VLAKLPLAEEEKRFAGKAGGKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILMRNQNLVGLKLPDLSEAAEQEKGLPSEL
SQ  SPAIEEEESKSGLDVMPNISDVLLRKLRVHRSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEEN
SQ  TEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVRQEKRMSKATEVMMQYVENLKRTYE
SQ  KDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLTLGKNMPRRRVSVAVVPKFNALNLPGQTPSSSSIPSLPALSES
SQ  PNGKGSLPVTSALPALLENGKTNGDPDCEASAPALTLSCLEELSQETKARMEEEAYSKGFQEGLKKTKELQDLKEEEEEQ
SQ  KSESPEEPEEVEETEEEEKGPRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAVMLVLTVVLGLYNSYNSCAEQADGPLGR
SQ  STCSAAQRDSWWSSGLQHEQPTEQ
//