ID  Q9Y6R4;
PN  Mitogen-activated protein kinase kinase kinase 4;
GN  MAP3K4;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
DR  UNIPROT: Q9Y6R4;
DR  UNIPROT: A6H8W0;
DR  UNIPROT: B7ZLD3;
DR  UNIPROT: B9EG75;
DR  UNIPROT: Q5VTT8;
DR  UNIPROT: Q5VTT9;
DR  UNIPROT: Q92612;
DR  UNIPROT: Q9H408;
DR  Pfam: PF19431;
DR  Pfam: PF00069;
DR  PROSITE: PS00107;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DR  OMIM: 602425;
DR  DisGeNET: 4216;
DE  Function: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
DE  Reference Proteome: Yes;
DE  Interaction: P12270; IntAct: EBI-3443161; Score: 0.00
DE  Interaction: Q14289; IntAct: EBI-7426200; Score: 0.46
DE  Interaction: Q9NRD5; IntAct: EBI-21380388; Score: 0.00
DE  Interaction: P52564; IntAct: EBI-448103; Score: 0.52
DE  Interaction: Q9Y6R4; IntAct: EBI-448214; Score: 0.37
DE  Interaction: P24522; IntAct: EBI-448179; Score: 0.37
DE  Interaction: O75293; IntAct: EBI-448183; Score: 0.57
DE  Interaction: O95257; IntAct: EBI-448198; Score: 0.37
DE  Interaction: P29350; IntAct: EBI-7426234; Score: 0.40
DE  Interaction: P07355; IntAct: EBI-7426270; Score: 0.40
DE  Interaction: Q96B97; IntAct: EBI-7862134; Score: 0.59
DE  Interaction: P0CG48; IntAct: EBI-7862277; Score: 0.52
DE  Interaction: O75369; IntAct: EBI-8585510; Score: 0.50
DE  Interaction: Q7Z7A1; IntAct: EBI-3443147; Score: 0.00
DE  Interaction: P63104; IntAct: EBI-3443168; Score: 0.00
DE  Interaction: P60953; IntAct: EBI-6590248; Score: 0.27
DE  Interaction: P46734; IntAct: EBI-6590776; Score: 0.27
DE  Interaction: O15264; IntAct: EBI-6590847; Score: 0.27
DE  Interaction: Q562R1; IntAct: EBI-21540493; Score: 0.35
DE  Interaction: Q8N7X8; IntAct: EBI-21585341; Score: 0.35
DE  Interaction: Q5VX52; IntAct: EBI-21635815; Score: 0.35
DE  Interaction: Q06187; IntAct: EBI-21836035; Score: 0.35
DE  Interaction: Q9UHD2; IntAct: EBI-20200875; Score: 0.35
DE  Interaction: Q9Y4C4; IntAct: EBI-20590738; Score: 0.44
DE  Interaction: P62851; IntAct: EBI-20903808; Score: 0.40
DE  Interaction: Q14137; IntAct: EBI-20912982; Score: 0.40
GO  GO:0005737;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0004709;
GO  GO:0046872;
GO  GO:0106310;
GO  GO:0060718;
GO  GO:0035556;
GO  GO:0019100;
GO  GO:0000165;
GO  GO:0001890;
GO  GO:0043507;
GO  GO:1900745;
GO  GO:0051973;
GO  GO:1904355;
GO  GO:0032212;
GO  GO:0006468;
GO  GO:0010468;
GO  GO:0010225;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENL
SQ  YGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKN
SQ  VQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
SQ  KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGT
SQ  SVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNIT
SQ  KDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
SQ  SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIA
SQ  LVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPA
SQ  GEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
SQ  SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRA
SQ  LKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLL
SQ  NAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
SQ  AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGY
SQ  NFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQA
SQ  LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
SQ  AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTL
SQ  ISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC
SQ  ISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
SQ  RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE
SQ  GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF
SQ  VKVCTDEE
//