ID  Q9YGI5;
PN  Deoxyribonuclease-1;
GN  DNASE1;
OS  9031;
SL  Nucleus Position: SL-0178;
SL  Comments: Secreted {ECO:0000250|UniProtKB:P24855}. Zymogen granule {ECO:0000250|UniProtKB:P24855}. Nucleus envelope {ECO:0000250|UniProtKB:P24855}. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope. {ECO:0000250|UniProtKB:P24855}.
DR  UNIPROT: Q9YGI5;
DR  Pfam: PF03372;
DR  PROSITE: PS00919;
DR  PROSITE: PS00918;
DE  Function: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:12739897). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (By similarity). Binds specifically to G-actin and blocks actin polymerization (By similarity). {ECO:0000250|UniProtKB:P21704, ECO:0000250|UniProtKB:P24855, ECO:0000269|PubMed:12739897}.
DE  Reference Proteome: Yes;
GO  GO:0005576;
GO  GO:0005635;
GO  GO:0042588;
GO  GO:0003779;
GO  GO:0004530;
GO  GO:0006915;
GO  GO:0000737;
GO  GO:0002283;
GO  GO:0002673;
GO  GO:0070948;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MARLVLELLAAALLLRVAATLRISAFNIRTFGDSKMSNQTVAGFIVSILVQYDITLVQEVRDADLSSVKKLVSQLNSASS
SQ  YPYSFLSSIPLGRNSYKEQYVFIYRSDIVSVLESYYYDDGCESCGTDIFSREPFIVKFSSPTTQLDEFVIVPLHAEPSSA
SQ  PAEINALTDVYTDVINKWETNNIFFMGDFNADCSYVTAEQWPSIRLRSLSSCEWLIPDSADTTVTSTDCAYDRIVACGSA
SQ  LRQAVEYGSATVNNFQETLRIQNKDALAISDHFPVEVTLKAR
//