ID  Q9Z0P5;
PN  Twinfilin-2;
GN  Twf2;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19955359}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000269|PubMed:19774077, ECO:0000269|PubMed:19955359}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. Isoform 2 found also along myofibrils in cardiomyocytes (PubMed:18837697). Localized in cochlea hair cells to the tips of the middle and short rows of stereocilia (PubMed:19955359). {ECO:0000269|PubMed:18837697, ECO:0000269|PubMed:19955359}.
DR  UNIPROT: Q9Z0P5;
DR  UNIPROT: Q3TD06;
DR  UNIPROT: Q3TZG2;
DR  UNIPROT: Q8BN77;
DR  UNIPROT: Q9DCK8;
DR  PDB: 7DS3;
DR  Pfam: PF00241;
DR  PROSITE: PS51263;
DE  Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. {ECO:0000269|PubMed:18837697, ECO:0000269|PubMed:19955359}.
DE  Reference Proteome: Yes;
DE  Interaction: P52927; IntAct: EBI-9986179; Score: 0.35
DE  Interaction: Q93KQ6; IntAct: EBI-16142792; Score: 0.35
GO  GO:0005884;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0030175;
GO  GO:0030426;
GO  GO:0030027;
GO  GO:0030016;
GO  GO:0048471;
GO  GO:0032420;
GO  GO:0051015;
GO  GO:0003785;
GO  GO:0005524;
GO  GO:0005546;
GO  GO:0005080;
GO  GO:0030042;
GO  GO:0051016;
GO  GO:0030030;
GO  GO:0071363;
GO  GO:0071300;
GO  GO:0035556;
GO  GO:0030837;
GO  GO:0045773;
GO  GO:0010592;
GO  GO:0010976;
GO  GO:0032956;
GO  GO:0010591;
GO  GO:0032532;
GO  GO:0042989;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQG
SQ  FEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRIN
SQ  EVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEPTNVAQLPSRIPRDAARYHFFL
SQ  YKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFK
SQ  QAFAKPKGPGGKRGHKRLIRGPGENGEDS
//