ID  Q9Z1K7;
PN  Adenomatous polyposis coli protein 2;
GN  Apc2;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O95996}. Golgi apparatus {ECO:0000250|UniProtKB:O95996}. Cytoplasm {ECO:0000250|UniProtKB:O95996}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O95996}. Note=Associated with actin filaments. Associated with microtubule network. {ECO:0000250|UniProtKB:O95996}.
DR  UNIPROT: Q9Z1K7;
DR  Pfam: PF05956;
DR  Pfam: PF16689;
DR  Pfam: PF05923;
DR  Pfam: PF18797;
DR  Pfam: PF00514;
DR  Pfam: PF05924;
DE  Function: Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1. {ECO:0000250|UniProtKB:O95996}.
DE  Reference Proteome: Yes;
DE  Interaction: P35922; IntAct: EBI-16728828; Score: 0.35
GO  GO:0005884;
GO  GO:0030877;
GO  GO:0016342;
GO  GO:0005737;
GO  GO:0005881;
GO  GO:0005829;
GO  GO:0031941;
GO  GO:0005794;
GO  GO:0045171;
GO  GO:0031258;
GO  GO:0015630;
GO  GO:0030496;
GO  GO:0048471;
GO  GO:0098794;
GO  GO:0008013;
GO  GO:0045295;
GO  GO:0008017;
GO  GO:0090630;
GO  GO:0001708;
GO  GO:0016477;
GO  GO:0000226;
GO  GO:0090090;
GO  GO:0007026;
GO  GO:0007399;
GO  GO:0007389;
GO  GO:0045732;
GO  GO:0043161;
GO  GO:0045595;
GO  GO:0016055;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTSSMASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQ
SQ  TDISSLYNLKFHAPALGPEPAARTPEGSPVHGSGPSKDSFGELSRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQ
SQ  GLSKRLDELPHVDTFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQAL
SQ  LAVKPVAVEEEQEAEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQIL
SQ  HGTEAGSVGRAGIPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTETPVPI
SQ  EPQICQATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCAR
SQ  RGCMEAIVAQLGSESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMECVLRASKESTLKSVLSALWNLSAHSTEN
SQ  KAAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACG
SQ  TLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQAAAMAVSPGTCVPSLYVRKQRALE
SQ  AELDTRHLVHALGHLEKQSLPEAETTSKKPLPPLRHLDGLVQDYASDSGCFDDDDAPSLAAAATTAEPASPAVMSMFLGG
SQ  PFLQGQALARTPPARQGGLEAEKEAGGEAAVAAKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDPGQEAPREGR
SQ  AQSCSPCRGTEGGRREAGSRAHPLLRLKAAHTSLSNDSLNSGSTSDGYCTREHMTPCPLAALAEHRDDPVRGQTRPRRLD
SQ  LDLPSRAELPARDTAATDARVRTIKLSPTYQHVPLLDGAAGAGVRPLVGPGTSPGARKQAWIPADSLSKVPEKLVASPLP
SQ  IASKVLQKLVAQDGPMSLSRCSSLSSLSSTGHAVPSQAENLDSDSSLEGLEEAGPGEAELGRAWRASGSTSLPVSIPAPQ
SQ  RGRSRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESRSIASSIPSDPCSGLGSGTVSPSELPDSPGQTMPPSR
SQ  SKTPPAPPGQPETSQFSLQWESYVKRFLDIADCRERCQPPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQQDVE
SQ  LRLRPPACPERAVGGGGHRRRDEAASRLDGPAPAGSRARSATDKELEALRECLGAAMPARLRKVASALVPGRRSLPVPVY
SQ  MLVPAPARGDDSGTDSAEGTPVNFSSAASLSDETLQGPSRDKPAGPGDRQKPTGRAAPARQTRSHRPKAAGAGKSTEHTR
SQ  GPCRNRAGLELPLSRPQSARSNRDSSCQTRTRGDGALQSLCLTTPTEEAVYCFYDSDEEPPATAPPPRRASAIPRALKRE
SQ  KPAGRKETPSRAAQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEAPEQPANHARGPEQGSKQDSSPSPRAEEELLQ
SQ  RCISLAMPRRRTQVPGSRRRKPRALRSDIRPTEITQKCQEEVAGSDPASDLDSVEWQAIQEGANSIVTWLHQAAAKASLE
SQ  ASSESDSLLSLVSGVSAGSTLQPSKLRKGRKPAAEAGGAWRPEKRGTTSTKINGSPRLPNGPEKAKGTQKMMAGESTMLR
SQ  GRTVIYSAGPASRTQSKGISGPCTTPKKTGTSGTTQPETVTKAPSPEQQRSRSLHRPGKISELAALRHPPRSATPPARLA
SQ  KTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGSLVPKSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLARPSP
SQ  EPGSRGRAGAEGTPGARGSRLGLVRMASARSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTASTSQAASPRR
SQ  GRPALPAVFLCSSRCDELRVSPRQPLAAQRSPQAKPGLAPLAPRRTSSESPSRLPVRASPGRPETVKRYASLPHISVSRR
SQ  SDSAVSVPTTQANATRRGSDGEARPLPRVAPPGTTWRRIKDEDVPHILRSTLPATALPLRVSSPEDSPAGTPQRKTSDAV
SQ  VQTEDVATSKTNSSTSPSLESRDPPQAPASGPVAPQGSDVDGPVLTKPPASAPFPHEGLSAVIAGFPTSRHGSPSRAARV
SQ  PPFNYVPSPMAAATMASDSAVEKAPVSSPASLLE
//