ID  Q9Z1W6;
PN  Protein LYRIC;
GN  Mtdh;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0198;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain. TNF- alpha causes translocation from the cytoplasm to the nucleus (By similarity). {ECO:0000250}.
DR  UNIPROT: Q9Z1W6;
DR  Pfam: PF15686;
DE  Function: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: P19357; IntAct: EBI-921030; Score: 0.35
DE  Interaction: Q96RT1; IntAct: EBI-22258042; Score: 0.35
DE  Interaction: P35968; IntAct: EBI-22252438; Score: 0.35
DE  Interaction: O75096; IntAct: EBI-22258804; Score: 0.35
DE  Interaction: O75886; IntAct: EBI-22259612; Score: 0.35
GO  GO:0016324;
GO  GO:0005923;
GO  GO:0005737;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0046581;
GO  GO:0016604;
GO  GO:0031965;
GO  GO:0005730;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0003725;
GO  GO:0051059;
GO  GO:0061629;
GO  GO:0003713;
GO  GO:0003712;
GO  GO:0070830;
GO  GO:0031663;
GO  GO:0043066;
GO  GO:0000122;
GO  GO:0045766;
GO  GO:0010508;
GO  GO:0043123;
GO  GO:0051092;
GO  GO:0051897;
GO  GO:0006357;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEPKRYPSWVILVGTGALGLLLLFLLGYGWAAACAGARK
SQ  KRRSPPRKREEVTPPTPAPEDPAQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEIPEDEVVRTPRSITAKQPPETDKKNEK
SQ  SKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFP
SQ  VGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENITVNGGGWSEKSVKLSSQLSAGEEKWNSVPPASAGKRKTEQSA
SQ  WTQDPGDTNANGKDWGRNWSDRSIFSGIGSTAEPVSQSTTSDYQWDGSRNQPHIDDEWSGLNGLSSADPSSDWNAPAEEW
SQ  GNWVDEDRASLLKSQEPISNDQKDSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSITQDTEDLEKDTREELPVNTSKAR
SQ  PKQEKACSLKTMSTSDPVEVLIKNSQPIKTLPPAISAEPSVTLSKGDSDKSSSQVPPMLQDTDKPKSNAKQNSVPPSQTK
SQ  SETNWESPKQIKKKKKARRET
//