ID  Q9Z270;
PN  Vesicle-associated membrane protein-associated protein A;
GN  Vapa;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24262037}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9P0L0}. Cell membrane {ECO:0000250|UniProtKB:Q9P0L0}; Single-pass type IV membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9P0L0}. Nucleus membrane {ECO:0000269|PubMed:24262037}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. {ECO:0000250|UniProtKB:Q9P0L0}.
DR  UNIPROT: Q9Z270;
DR  UNIPROT: Q6P723;
DR  PDB: 1Z9L;
DR  PDB: 1Z9O;
DR  Pfam: PF00635;
DR  PROSITE: PS50202;
DE  Function: Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (By similarity). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (By similarity). With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking (PubMed:19289470). {ECO:0000250|UniProtKB:Q9P0L0, ECO:0000269|PubMed:19289470}.
DE  Reference Proteome: Yes;
DE  Interaction: P21708; IntAct: EBI-7626952; Score: 0.35
DE  Interaction: P37840; IntAct: EBI-2909386; Score: 0.35
DE  Interaction: Q8K4M9; IntAct: EBI-15554458; Score: 0.65
DE  Interaction: Q9Z270; IntAct: EBI-15554502; Score: 0.56
DE  Interaction: Q9BYV6; IntAct: EBI-21998606; Score: 0.35
DE  Interaction: Q5XIE8; IntAct: EBI-26438079; Score: 0.35
GO  GO:0005923;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0000139;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0015630;
GO  GO:0031965;
GO  GO:0005886;
GO  GO:0031982;
GO  GO:0033149;
GO  GO:0042802;
GO  GO:0008017;
GO  GO:0019904;
GO  GO:0046982;
GO  GO:0044877;
GO  GO:0008219;
GO  GO:0035627;
GO  GO:0090114;
GO  GO:0006888;
GO  GO:0044828;
GO  GO:0031175;
GO  GO:0015914;
GO  GO:0044829;
GO  GO:0070972;
GO  GO:0006686;
GO  GO:0015918;
GO  GO:0019076;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MASASGAMAKHEQILVLDPPSDLKFKGPFTDVVTTNLKLQNPSDRKVCFKVKTTAPRRYCVRPNSGVIDPGSIVTVSVML
SQ  QPFDYDPNEKSKHKFMVQTIFAPPNISDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPLP
SQ  KPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSAVSFRDNVTSPLPSLLVVIAAIFI
SQ  GFFLGKFIL
//