ID  Q9Z2G9;
PN  Oxidoreductase HTATIP2;
GN  Htatip2;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm {ECO:0000250}. Nucleus envelope {ECO:0000250}.
DR  UNIPROT: Q9Z2G9;
DR  UNIPROT: Q810Y5;
DR  UNIPROT: Q99KN6;
DR  UNIPROT: Q9D5F8;
DR  UNIPROT: Q9D804;
DR  PDB: 2FMU;
DR  Pfam: PF13460;
DE  Function: Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. {ECO:0000269|PubMed:14695192}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005635;
GO  GO:0051287;
GO  GO:0016620;
GO  GO:0004674;
GO  GO:0001525;
GO  GO:0006915;
GO  GO:0030154;
GO  GO:0051170;
GO  GO:0043068;
GO  GO:0045944;
GO  GO:0046777;
GO  GO:0045765;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MADKEALPKLREDFKMQNKSVFILGASGETGKVLLKEILGQNLFSKVTLIGRRKLTFEEEAYKNVNQEVVDFEKLDVYAS
SQ  AFQGHDVGFCCLGTTRSKAGAEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSRGADKSSSFLYLQVKGEVEAKVEELKFD
SQ  RLSVFRPGVLLCDRQESRPGEWLARKFFGSLPDSWASGYAVPVVTVVRAMLNNLVSPSSGQMELLENKAILHLGKDRDVP
SQ  KL
//