ID  V5IVB1;
PN  cap-snatching endonuclease;
GN  RdRp;
OS  1980460;
SL  Nucleus Position: SL-0382;
SL  Comments: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q9YQR5}.
DR  UNIPROT: V5IVB1;
DR  Pfam: PF04196;
DR  Pfam: PF12426;
DR  PROSITE: PS50525;
DE  Function: RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate (By similarity). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap- snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. Cleaves ssRNA substrates but not DNA (By similarity). Seems to downregulate the expression of its own and heterologous mRNAs through its endonuclease activity (By similarity). {ECO:0000250|UniProtKB:Q9E005}.
DE  Reference Proteome: No;
GO  GO:0044220;
GO  GO:0004519;
GO  GO:0046872;
GO  GO:0000166;
GO  GO:0003968;
GO  GO:0075526;
GO  GO:0006351;
GO  GO:0039694;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEKYREIHQRVREIAPGTGSALDCMDLLDRLYAVRHDLVDQMIKHDWSDNKDVETPIGQVLLMAGVPNDIIQGMEKKIIP
SQ  NSPTGQILKSFFKMTPDNFKITGNQIEFIEVTVTADVARGIREKRLKYESGLRFTEELLELEVKKGNLQQVYRISFNVVA
SQ  VKTDGSNISTQWPSRRNEGVVQQMRLVQADINYVREHLIMQDERASLEAMFNLKFHVTGPRLRYFSIPDYRPQPLCNPTI
SQ  DGLLQYCKQWLTEEHKFIFKEVSGTNVMGSFEVNEKKHKERYLESRKPRNFLLLQTTIQGSYLPSTISSDQCNTRIGCLE
SQ  ICKNIPETPVQALASDIAFKYISLDKDEVINYYNPRIHFKPGQNVKEPGTLKIGLSQMNPLSKAILDNIGKHKSDKGLFG
SQ  QAIESINIASQIQLNECSKVIEQILSNLEINISDVSENIPLPKKTTCVDELLGKFYENEITKYMLGILRKTVAWHIGHLI
SQ  RDITESLIAHSGLRRSKYWSVHAYDHGNVILFILPSKSLEVAGSYIRFFTVFKDGIGLVDNDNTDSKTEIDGITWIYSKV
SQ  MSIDLNRLLALNIAFEKALLATATWFQYYTEDQGHFPLQHALRSVFSFHLLLCVSQKMKICAIFDNLRYLIPSVTSLYSG
SQ  YELLIEKFFERPFKSALDVYLYSIIKSLLVSLAQNNKVRFYSKVRLLGLTVDQSTVGASGVYPSLMSRVVYKHYRSLISE
SQ  ATTCFFLFEKGLHGNLTEEAKIHLETVEWARKFNEKENRYGDILMKEGYTIELVENQNVTVEQQLFCQEVVELSAMELNK
SQ  YLHAKSQVLCANIMNKHWDKPYFSQVRNISLKGMSGSLQEDGHLASSVTLIEAIRFLNSSQINPNVIDMYERTKHCKAQA
SQ  RIVRKYQRTEADRGFFITTLPTRVRLEIIEDYYDAIAKVVPEEYISYGGERKILNIQSALEKALRWASGISEIITSTGKK
SQ  IRFKRKLMYVSADATKWSPGDNSAKFRRFTQAIYDGLNDDKLKCCVVDSLKNIYETEFFMSRKLHRYIDSMESKSEAVED
SQ  FLSFFSGGVSATVKGNWLQGNLNKCSSLFGVAVSLLFKRVWVELFPELECFFEFAHHSDDALFIYGYLEPEDDGTDWFMY
SQ  VSQQIQAGHYHWHAVNQEMWKSMFNLHEQLLLMGSIRVSPKKTTVSPTNAEFLSTFFEGCAVSIPFIKILLGSLSDLPGL
SQ  GFFDDLAASQSRCVKALDLGACPQLAQLAIVLCTSKVERLYGTADGMINSPISFLKVNKAHIPIALGGDGSMSIMELATA
SQ  GIGMADKNILKKAFYSYKHTKRDGDRYILGLFKFLMSLSDDVFQHDRLGEFSFVGKVQWKVFTPKSEFEFYDQYSMTYLQ
SQ  AWSKQHPVYDYIIPRGRDNLLVYLVRKLNDPSIITAMTMQSPLQLRFRMQAKQHMKVCKLEGEWVTFREILAAADSFAST
SQ  YQPNEKDLDLFNTLVSCTFSKEYAWKDFLNEVRCEVTTARHVHRPKVARTFTVREKDQVIQNPITSVIGYKYASTVDEIS
SQ  DVLDSAFFPDSLSADLQVMKEGVYRELGLDIGLPEVLKRIAPLLYKAGKSRIVIVEGNIEGTAESICSYWLKNMSLIKTI
SQ  KVKPRKEVLKAVSLYGTKDNLSLQDDLAATRICIEVWRWCKANNQNVQEWFTALYFENQTLYDWIERFRRKGVVPVDPEI
SQ  QCMALLLYDVLGFKNVLQMQANRRAYSGKQYDAYCVQTYNEETKLYEGDLRVTFNFGLDCARLEVFWDKKEYVLETSITQ
SQ  KHVLRLMMEEVSKELVRCGMRFKTEQVSHTRSLVLFKTESGFEWGKPNIPCIVYKHCALRTGLRTKHPINKEFMINIQSD
SQ  GFRAIAQMDIESPRFLLAHAYHTLRDVRYQAVQAVGNVWFRTEQHKLFINPIISSGLLENFMKGLPAAIPPAAYSLIMNK
SQ  AKISVDLFMFNELLALINKNNILDLSGIEETSEGYSTVTSMSSKQWSEEMSLMSDDDIDDDEEFTIALDDIDFEQVDLEE
SQ  DIQHFLQDESAYVGDLLIQTEEVEVKRIRGVTRILEPVKLIKSWVSKGLAIDKVYNPVGILLMARYMSKNYDFHSVPLAL
SQ  MNPYDLTEFESVVKGWGETINDRFQEIDLEAQRLVREQNIQPEDILPDSLFSFRHVDVLLKRLFPRDPISSFY
//