O01477 Protein simr 6239 None SL-0198 Cytoplasm, perinuclear region {ECO:0000269|PubMed:32338603}. Note=Localizes to perinuclear foci in germ cells, called SIMR foci, which are distinct from Mutator foci, P granules and Z granules (PubMed:32338603). SIMR foci are stacked, with znfx-1 localizing between simr-1 and pgl-1 (PubMed:32338603). Its localization at SIMR foci is adjacent to the mutator complex protein mut-16 (PubMed:32338603). Perinuclear localization is not dependent on mut-16 (PubMed:32338603). {ECO:0000269|PubMed:32338603}. UNIPROT O01477 Acts downstream of piRNA production to promote mediator complex-dependent endogenous siRNA biogenesis from piRNA-target mRNAs in the RNA interference pathway in germ cells (PubMed:32338603). Not required to identify target mRNA by the piRNA pathway (PubMed:32338603). Plays a role in both spermatogenesis and oogenesis and in maintaining fertility over multiple generations, probably by directing mutator-dependent silencing to piRNA-targeted genes (PubMed:32338603). {ECO:0000269|PubMed:32338603}. GO:0048471 GO:0090727 GO:1905881 GO:0030422 GO:0007283 Unknown UniProt Sequence Analysis MSNEKQQWDDAYCLAEEMHDAGRPFKREELNIADQFICSRFSTIFEYDPYKDTYGFRNQELTHAIPVKSKCRHISDVDILELKKNTANADIRFPSYLNICPVYAMHPFTVLAFDLSKPVPMGMNASMENAAPNMKSPTEAEITPGTIYIFKHRDNKCYRCVILFEDGDNNVSDADRKYMVAFLDTPQVVSVKLKTLFHLGKFTIESYPCALYCCRAVGILEIRKDFGADLNGQINEFYKDKVKRKSGVHALIYKKDDRGDKLIFDCPSILGTSMTMALEIKDVIGHRSVAENDPTALSYDELVSKQLPTVDIDDHNSSVVLDLEESVIAQELGSTNGADCPCNNDNIDDFMQSQRQNPLDNNRDNWDRINESRSSMQSFAINQSQAITANPTPQPTFDESSGEVQTIPESINNLALNGRYLEDGRGTEEIREERSVESRQIGNQVVSQASCNYLEARQNSTQTANAESVCAIISESHAALPTDIQVIPSQHVLNENNHTVLPSVAPIIRNATGHSHIFGRQIPSPAFRRESLSSGNSIQVATFAATTGPCGSNTSRPTAQNTANSSINQDMSISNSSTNARLITIAQDNLNDTENWPNSEREQSATEMESGAEATTNSAVDEFAQVSDDMKGLADSMINFLRLTANSNNQDAFKANIFAMELISTKIPNQLTKRFFTLKIAEAKSLAEGFN 691