O60583 Cyclin-T2 CCNT2 9606 None SL-0198 Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TQK0}. Nucleus {ECO:0000250|UniProtKB:Q7TQK0}. Note=Nucleus in differentiating cells. {ECO:0000250|UniProtKB:Q7TQK0}. UNIPROT O60583 UNIPROT A8KA48 UNIPROT D3DP73 UNIPROT D3DP74 UNIPROT O60582 UNIPROT Q29R66 UNIPROT Q53SR4 UNIPROT Q5I1Y0 PDB 2IVX Pfam PF00134 OMIM 603862 DisGeNET 905 Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}. (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269|PubMed:21509660}. A0A3Q0PRD7 EBI-2836754 0.00 O95402 EBI-4324040 0.35 Q9UHB7 EBI-4324092 0.35 O00472 EBI-4324079 0.35 P42568 EBI-4324106 0.35 P50750 EBI-4324121 0.85 O60885 EBI-9077135 0.35 Q6NYC1 EBI-9077105 0.40 Q16659 EBI-12502733 0.35 A3KMF4 EBI-11085933 0.35 Q9ERL0 EBI-11086053 0.35 Q9HB65 EBI-21631556 0.35 Q9P0M6 EBI-21731516 0.35 Q96MH2 EBI-21764590 0.35 O94992 EBI-21776048 0.35 Q00534 EBI-21776141 0.35 P14404 EBI-21026252 0.35 Q12802 EBI-25409729 0.35 Q07139 EBI-25410964 0.35 P83105 EBI-25745135 0.35 O60583 EBI-25684887 0.35 A0A0F6B063 EBI-27033283 0.35 D0ZRB2 EBI-27033344 0.35 GO:0008024 GO:0005829 GO:0005654 GO:0005634 GO:0048471 GO:0005886 GO:0097322 GO:0003682 GO:0061575 GO:0016538 GO:0019901 GO:0070063 GO:0001223 GO:0007049 GO:0051301 GO:0019085 GO:0019086 GO:0032786 GO:0045944 GO:0032968 GO:0006468 GO:0000079 GO:0051147 GO:0006357 GO:0007519 GO:0006366 Unknown UniProt Sequence Analysis MASGRGASSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNKNIISSTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVILETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPNRLKKIRNWRANQAARKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPTNPSFQKPSTSAFPAPVPLNSGNISVQDSHTSDNLSMLATGMPSTSYGLSSHQEWPQHQDSARTEQLYSQKQETSLSGSQYNINFQQGPSISLHSGLHHRPDKISDHSSVKQEYTHKAGSSKHHGPISTTPGIIPQKMSLDKYREKRKLETLDLDVRDHYIAAQVEQQHKQGQSQAASSSSVTSPIKMKIPIANTEKYMADKKEKSGSLKLRIPIPPTDKSASKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSSRHHTSSHKHSHSHSGSSSGGSKHSADGIPPTVLRSPVGLSSDGISSSSSSSRKRLHVNDASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVETNGPDANHEYSTSSQHMDYKDTFDMLDSLLSAQGMNM 730