P0CW70 Probable Dpy19l2 10090 None SL-0178 SL-0179 SL-0182 Nucleus inner membrane {ECO:0000269|PubMed:22764053, ECO:0000269|PubMed:34471926}; Multi-pass membrane protein {ECO:0000305}. Note=Restricted to the inner nuclear membrane facing the acrosomal vesicle. The N- and C-termini are oriented towards the nucleoplasm (PubMed:22764053). Colocalizes with FAM209 at the inner nuclear membrane (PubMed:34471926). {ECO:0000269|PubMed:22764053, ECO:0000269|PubMed:34471926}. UNIPROT P0CW70 Pfam PF10034 Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250|UniProtKB:P34413}. Required during spermatogenesis for sperm head elongation and acrosome formation. Also plays a role in acrosome attachment to the nuclear envelope. {ECO:0000269|PubMed:22764053, ECO:0000269|PubMed:34471926}. GO:0016021 GO:0005637 GO:0000030 GO:0018406 GO:0007286 Transmembrane UniProt Sequence Analysis {ECO:0000255} MVGPTRSKLREGSSDRPQSSCTGQARRRWSAATMEPQQERSAPQERTKWSLLQHFLLGGRKLPSGARNYAARRIQSLNAQNYFQLEEVAKLLLLNRFQFLFTLLDHFREKVQALQMHRFSHRTLFGLAIFVGILHWLHLITLFENDHHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLVINTVKRFHLYPEVVIAYWYRTIIGIMNLFGIETKTCWNVTRMEPLNEVQSCEGLGDPACFYIGVIFILNGLMMGLFFIYSTYLSGSQLGGLITVACYFFNHGEATRVMWTPPLRESFSYPFLVLQMYILTIILRTSTVHKKHYMALCFSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKIIYVNMSSVALCFILMFGNSMYLSSYYSSCLLVTWAIMQKKSKIQKLGGTELQFWLIQGCFWWCGTIILKFLTSKICGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMEQATPLRYIKTLLLPLILVITYLIFKKIVRDIMCVLYTNTYVRKQLLDNAELIFHTLQLLAFTGLAILIMRLKLFLTPHMCIMASLICSQRLFGWLFCRIHFENVVFGILTMMSIQGCANLHNQWSIMGEFTNLPQEELIHWIKHSTRPDAVFAGAMPTMASIKLSTLRPIVNHPHYEDADLRARTKIVYSVYSRKSAVEVRNNLLKLHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSILLKDSRPYFTTVFQNSMYRVLKIN 773