<Entry>
<Accession>P0DPK0</Accession>
        <ProteinName>Protein</ProteinName>
        <GeneName>custos</GeneName>
        <OS_id>8355</OS_id>
        <ReferenceProteome>None</ReferenceProteome>
        <SubcellularLocation>
<Location>SL-0178</Location>
<Comments>Nucleus envelope {ECO:0000269|PubMed:25157132}.</Comments>
</SubcellularLocation>
<CrossReferences>
<CrossReference>
<Database>UNIPROT</Database>
<ID>P0DPK0</ID>
</CrossReference>
</CrossReferences>
<Function>Essential for Spemann-Mangold organizer formation and subsequent anterior head development in the embryo. Inhibits canonical Wnt signaling pathway by antagonizing nuclear import of beta-catenin (ctnnb1) during embryogenesis. {ECO:0000269|PubMed:25157132}.</Function>
<OntologyTerms>
<Ontology>GO:0005635</Ontology>
<Ontology>GO:0030178</Ontology>
<Ontology>GO:0060061</Ontology>
<Ontology>GO:0016055</Ontology>
</OntologyTerms>
<Topology>
        <Type>Unknown</Type>
        <Source>UniProt</Source>
        <Annotation>Sequence Analysis</Annotation>
        </Topology>
<Sequence>MAAPRRGTQKSDSDSSDEDLDRFREAAWVPPGAHQKVSDEQNEKIALPSLRVRPDCHEHDGNELQTTPEFRSHVAKKLAAILDSSIREVSQNEAVHISKAGNGDSEDEGFRLFRTSLPGEAGIVTSTIPRRKLASSSSEDSEEEQQRCREAAVSACDILRHSTLQQEPQSTPSNVCDNQPPKKKRKKKKKDRGDTSQINSVEETMHIEPGKNELQAKRKKKKKQKLEMAHCDELGNE</Sequence>
        <SequenceLength>237</SequenceLength>
        </Entry>