P49021 Protein tim 7227 None SL-0198 Nucleus {ECO:0000269|PubMed:8625406}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8625406}. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with per is required for nuclear localization. UNIPROT P49021 UNIPROT A4V040 UNIPROT B7Z007 UNIPROT B7Z008 UNIPROT C9QPB7 UNIPROT M9MRE9 UNIPROT O44380 UNIPROT Q1WWF5 UNIPROT Q59E16 UNIPROT Q8I037 UNIPROT Q95U67 UNIPROT Q9VQR6 UNIPROT Q9VQR7 Pfam PF04821 Pfam PF05029 Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. {ECO:0000269|PubMed:7481772, ECO:0000269|PubMed:7481773, ECO:0000269|PubMed:8128247, ECO:0000269|PubMed:8625406, ECO:0000269|PubMed:9504927}. O77059 EBI-872146 0.27 P07663 EBI-15772062 0.59 Q9Y156 EBI-266331 0.00 Q9V480 EBI-496420 0.37 Q9VQ30 EBI-496427 0.00 Q960S0 EBI-496435 0.00 P51123 EBI-496442 0.00 Q24432 EBI-496450 0.37 O61735 EBI-872058 0.27 P18431 EBI-874320 0.27 Q24568 EBI-9944837 0.35 Q9VDY1 EBI-9949981 0.35 M9NFI9 EBI-9959939 0.35 Q9V475 EBI-16005494 0.40 Q9VDE3 EBI-16005513 0.40 P08181 EBI-16073655 0.35 P08182 EBI-16073713 0.35 GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0048471 GO:0031298 GO:0003677 GO:0046982 GO:0008134 GO:0071482 GO:0048512 GO:0003053 GO:0060086 GO:0007620 GO:0006281 GO:0000076 GO:0008062 GO:0009649 GO:0045475 GO:0007617 GO:0046957 GO:0000122 GO:2000678 GO:0009648 GO:0050766 GO:0042749 GO:0045187 GO:0050764 GO:0042306 GO:0043111 GO:0048478 GO:0007622 Unknown UniProt Sequence Analysis MDWLLATPQLYSAFSSLGCLEGDTYVVNPNALAILEEINYKLTYEDQTLRTFRRAIGFGQNVRSDLIPLLENAKDDAVLESVIRILVNLTVPVECLFSVDVMYRTDVGRHTIFELNKLLYTSKEAFTEARSTKSVVEYMKHILESDPKLSPHKCDQINNCLLLLRNILHIPETHAHCVMPMMQSMPHGISMQNTILWNLFIQSIDKLLLYLMTCPQRAFWGVTMVQLIALIYKDQHVSTLQKLLSLWFEASLSESSEDNESNTSPPKQGSGDSSPMLTSDPTSDSSDNGSNGRGMGGGMREGTAATLQEVSRKGQEYQNAMARVPADKPDGSEEASDMTGNDSEQPGSPEQSQPAGESMDDGDYEDQRHRQLNEHGEEDEDEDEVEEEEYLQLGPASEPLNLTQQPADKVNNTTNPTSSAPQGCLGNEPFKPPPPLPVRASTSAHAQMQKFNESSYASHVSAVKLGQKSPHAGQLQLTKGKCCPQKRECPSSQSELSDCGYGTQVENQESISTSSNDDDGPQGKPQHQKPPCNTKPRNKPRTIMSPMDKKELRRKKLVKRSKSSLINMKGLVQHTPTDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKFAAQLELDMEHIDTILTYDVLSYLTYEGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTYNKVTHLNEDDKAHLRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDSSAKLGGCQTIRLSEHITQFATLEVMHYYGILLEDFNNNGEFVNDCIFTMMHHIGGDLGQIGVLFQPIILKTYSRIWEADYELCDDWSDLIEYVIHKFMNTPPKSPLTIPTTSLTEMTKEHNQEHTVCSWSQEEMDTLYWYYVQSKKNNDIVGKIVKLFSNNGNKLKTRISIIQQLLQQDIITLLEYDDLMKFEDAEYQRTLLTTPTSATTESGIEIKECAYGKPSDDVQILLDLIIKENKAQHLLWLQRILIECCFVKLTLRSGLKVPEGDHIMEPVAYHCICKQKSIPVVQWNNEQSTTMLYQPFVLLLHKLGIQLPADAGSIFARIPDYWTPETMYGLAKKLGPLDKLNLKFDASELEDATASSPSRYHHTGPRNSLSSVSSLDVDLGDTEELALIPEVDAAVEKAHAMASTPSPSEIFAVPKTKHCNSIIRYTPDPTPPVPNWLQLVMRSKCNHRTGPSGDPSDCIGSSSTTVDDEGFGKSISAATSQAASTSMSTVNPTTTLSLNMLNTFMGSHNENSSSSGCGGTVSSLSMVALMSTGAAGGGGNTSGLEMDVDASMKSSFERLEVNGSHFSRANNLDQEYSAMVASVYEKEKELNSDNVSLASDLTRMYVSDEDDRLERTEIRVPHYH 1398