P53895 Protein ASI2 559292 None SL-0178 SL-0179 SL-0182 Nucleus inner membrane {ECO:0000269|PubMed:17085444}; Multi-pass membrane protein {ECO:0000269|PubMed:17085444}. UNIPROT P53895 UNIPROT D6W124 Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation (PubMed:25236469). Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:17085444). Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748). {ECO:0000269|PubMed:11454748, ECO:0000269|PubMed:17085444, ECO:0000269|PubMed:25236469}. P38074 EBI-855745 0.00 P25294 EBI-3762277 0.35 P10592 EBI-3793098 0.35 P10614 EBI-10096421 0.40 P53983 EBI-10096480 0.46 P54074 EBI-10096457 0.46 GO:0097658 GO:0005783 GO:0016021 GO:0005637 GO:0071230 GO:0036369 GO:0006511 Transmembrane UniProt Curator Inference {ECO:0000305|PubMed:17085444} MARPQNHRRSNWTERDDNDDYLFQRFLEESETRHSREPSPVTEQSQQELQQDVQQAIDGIFNSLRRNMSSTSNINRAANMDATTNGNGGINADTIRATNANTADSPFTARQQSPLRTFLRNLFILDYFIGLILFPFSVYNILRSGFNSMTFSENDFIIEIVGYWKFAKIFGSGGTTLIAYKDTGKLGLLGKFHNIIVFYSSPVIKHIMKSRDGNEPNLNWIRLMFAKAFELFVKVSTILIYLAYGVSGTVYMVTAGFFFVLCLLFTVIRRYKGVHRMLVSQRITGPGVF 289